N-(2,4-Dichloro-5-methoxyphenyl)acetamide

Base Information

• Chemical Name: N-(2,4-Dichloro-5-methoxyphenyl)acetamide
• CAS No.: 65182-98-1
• Molecular Formula: C9H9Cl2NO2
• Molecular Weight: 234.082
• Hs Code.: 2924299090
• European Community (EC) Number: 613-753-0
• UNII: P98Z4RSG5D
• DSSTox Substance ID: DTXSID80561982
• Nikkaji Number: J275.429K
• Wikidata: Q72466667
• Mol file: 65182-98-1.mol

Synonyms:N-(2,4-DICHLORO-5-METHOXYPHENYL)ACETAMIDE;65182-98-1;24Dichloro-5methoxyacetanilide;2,4-Dichloro-5-methoxyacetanilide;P98Z4RSG5D;SCHEMBL9730411;DTXSID80561982;CTRIHOCZGTYVOA-UHFFFAOYSA-N;m-Acetanisidide, 4',6'-dichloro-;MFCD17014778;AKOS015890766;4L-311S;A8858;CS-0454607;Acetamide, N-(2,4-dichloro-5-methoxyphenyl)-;G71506

Chemical Property of N-(2,4-Dichloro-5-methoxyphenyl)acetamide

Chemical Property:

• Vapor Pressure: 5.17E-06mmHg at 25°C
• Melting Point: 158-159 °C
• Refractive Index: 1.583
• Boiling Point: 381.2 °C at 760 mmHg
• Flash Point: 184.3 °C
• PSA: 41.82000
• Density: 1.373 g/cm³
• LogP: 3.60990
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 233.0010339
• Heavy Atom Count: 14
• Complexity: 213

Purity/Quality:

98%min ^*data from raw suppliers

N-(2,4-Dichloro-5-methoxyphenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC(=C(C=C1Cl)Cl)OC
• Uses: N-(2,4-Dichloro-5-methoxyphenyl)acetamide is a reactant used in the chlorination of acetanilides with benzyltrimethylammonium tetrachloroiodate(B316185).

Technology Process of N-(2,4-Dichloro-5-methoxyphenyl)acetamide

There total 7 articles about N-(2,4-Dichloro-5-methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

m-methoxyacetanilide (588-16-9) → N-(2,4-dichloro-5-methoxybenzene)acetamide (65182-98-1)

Guidance literature:

With benzyltrimethylazanium tetrachloro-λ³-iodanuide; acetic acid; for 24h; Ambient temperature;

DOI:10.1246/bcsj.63.941

Reference yield: 81.0%

N-(2,4-dichloro-5-hydroxyphenyl)acetamide (67669-19-6) + dimethyl sulfate (77-78-1) → N-(2,4-dichloro-5-methoxybenzene)acetamide (65182-98-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 6h;

DOI:10.1055/s-0035-1560471

Reference yield:

methylene chloride (74-87-3) + N-(2,4-dichloro-5-hydroxyphenyl)acetamide (67669-19-6) → N-(2,4-dichloro-5-methoxybenzene)acetamide (65182-98-1)

Guidance literature:

With potassium carbonate; In acetonitrile; at 60 ℃; Solvent; Temperature; Reagent/catalyst; Autoclave;

upstream raw materials:

N-(2,4-dichloro-5-hydroxyphenyl)acetamide

dimethyl sulfate

m-methoxyacetanilide

meta-hydroxyacetanilide

Downstream raw materials:

bosutinib

7-(3-chloropropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-3-quinolinecarbonitrile

1,3-dichloro-4,6-dimethoxybenzene

2,4-dichloro-5-methoxyaniline

Refernces

• 1、 -. "A PROCESS FOR THE PREPARATION OF BOSUTINIB". Page/Page column 4; 5. . Retrieved 2019/10/23.
• 2、 -. "Herbicidal 1-aryl-4-substituted-1,4-dihydro-5H-tetrazol-5-ones and sulfur analogs thereof". . . Retrieved 2008/06/13.