3-<methyl>furan

Base Information

• Chemical Name: 3-<methyl>furan
• CAS No.: 84802-88-0
• Molecular Formula: C₁₂H₁₂O₄S
• Molecular Weight: 252.291
• Mol file: 84802-88-0.mol

Synonyms:3-<methyl>furan

Chemical Property of 3-<methyl>furan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-<methyl>furan

There total 1 articles about 3-<methyl>furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

furan-3-methanol (4412-91-3) + p-toluenesulfonyl chloride (98-59-9) → 3-<methyl>furan (84802-88-0)

Guidance literature:

With sodium hydroxide; In diethyl ether; at -20 ℃; for 3h;

DOI:10.1021/jo00155a038

Reference yield: 45.0%

lithium di-n-butylcuprate (24406-16-4) + 3-<methyl>furan (84802-88-0) → 3-n-pentylfuran (6177-84-0) + octane (111-65-9)

Guidance literature:

With ammonium chloride; In diethyl ether; 1.) -50 deg C, 4h, 2.) 0 deg C, 10 min;

DOI:10.1021/jo00155a038

Reference yield:

3-<methyl>furan (84802-88-0) → C22H25N3O5

Guidance literature:

Multi-step reaction with 5 steps

1.1: tBuLi / diethyl ether / 20 °C

1.2: diethyl ether / 20 °C

2.1: MgSO₄ / CH₂Cl₂ / 48 h / 20 °C

3.1: Et₃N / CH₂Cl₂

4.1: diethyl ether / -78 - -30 °C

4.2: H₅IO₆; MeNH₂ / methanol; H₂O / 20 °C

5.1: ethanol

With tert.-butyl lithium; magnesium sulfate; triethylamine; In diethyl ether; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2007.04.016

upstream raw materials:

furan-3-methanol

p-toluenesulfonyl chloride

Downstream raw materials:

3-n-pentylfuran

octane

3-ethylfuran

Refernces

• 1、 Chao, Jianhua,Taveras, Arthur G.,Chao, Jianping,Aki, Cynthia,Dwyer, Michael,Yu, Younong,Purakkattle, Biju,Rindgen, Diane,Jakway, James,Hipkin, William,Fosetta, James,Fan, Xuedong,Lundell, Daniel,Fine, Jay,Minnicozzi, Michael,Phillips, Jonathan,Merritt, J. Robert. "C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists". . p. 3778 - 3783. Retrieved 2008/02/10.