Technology Process of 5-[2,4-Dihydroxy-6-(4-nitrophenoxy)phenyl]-N-(1-methyl-4-piperidinyl)-3-isoxazolecarboxamide
There total 7 articles about 5-[2,4-Dihydroxy-6-(4-nitrophenoxy)phenyl]-N-(1-methyl-4-piperidinyl)-3-isoxazolecarboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-[2,4-dihydroxy-6-(4-nitrophenoxy)phenyl]isoxazole-3-carboxylic acid;
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate;
In
N,N-dimethyl acetamide;
at 20 ℃;
for 0.25h;
4-Amino-1-methylpiperidine;
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl acetamide;
at 20 ℃;
DOI:10.1016/j.bmc.2013.09.018
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / dimethyl sulfoxide / 2 h / 110 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -50 °C
2.2: 2 h / 20 °C
3.1: hydroxylamine hydrochloride / ethanol / 2 h / Reflux
4.1: boron tribromide / dichloromethane / 120 h / 0 - 20 °C
5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl acetamide / 0.25 h / 20 °C
5.2: 20 °C
With
hydroxylamine hydrochloride; boron tribromide; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; lithium hexamethyldisilazane;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2013.09.018
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -50 °C
1.2: 2 h / 20 °C
2.1: hydroxylamine hydrochloride / ethanol / 2 h / Reflux
3.1: boron tribromide / dichloromethane / 120 h / 0 - 20 °C
4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl acetamide / 0.25 h / 20 °C
4.2: 20 °C
With
hydroxylamine hydrochloride; boron tribromide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; lithium hexamethyldisilazane;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1016/j.bmc.2013.09.018
