5,5-dimethoxy-2-phenoxy-1,3,2-dioxaphosphorinane 2-oxide

Base Information

• Chemical Name: 5,5-dimethoxy-2-phenoxy-1,3,2-dioxaphosphorinane 2-oxide
• CAS No.: 231280-23-2
• Molecular Formula: C₁₁H₁₅O₆P
• Molecular Weight: 274.21
• Mol file: 231280-23-2.mol

Synonyms:5,5-dimethoxy-2-phenoxy-1,3,2-dioxaphosphorinane 2-oxide

Chemical Property of 5,5-dimethoxy-2-phenoxy-1,3,2-dioxaphosphorinane 2-oxide

Chemical Property:

• Solubility.: DCM, Methanol

Purity/Quality:

5,5-Dimethoxy-2-phenoxy-1,3,2-dioxaphosphorinane 2-Oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 5,5-Dimethoxy-2-phenoxy-1,3,2-dioxaphosphorinane 2-Oxide is an intermediate in the synthesis of Hydroxypyruvic Aicd Phosphate (H953190), one of the essential metabolite for microbial growth.

Technology Process of 5,5-dimethoxy-2-phenoxy-1,3,2-dioxaphosphorinane 2-oxide

There total 1 articles about 5,5-dimethoxy-2-phenoxy-1,3,2-dioxaphosphorinane 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

O-phenyl phosphorodichloridate (770-12-7) + 2,2-dimethoxypropane-1,3-diol (153214-82-5) → 5,5-dimethoxy-2-phenoxy-1,3,2-dioxaphosphorinane 2-oxide (231280-23-2)

Guidance literature:

With pyridine; for 20h; Ambient temperature;

DOI:10.1021/jo9823902

Reference yield: 55.0%

5,5-dimethoxy-2-phenoxy-1,3,2-dioxaphosphorinane 2-oxide (231280-23-2) → cyclohexylammonium 5,5-dimethoxy-2-oxo-1,3,2-dioxaphosphorinan-2-olate (1006694-13-8)

Guidance literature:

5,5-dimethoxy-2-phenoxy-1,3,2-dioxaphosphorinane 2-oxide; With barium dihydroxide; In water; at 96 - 98 ℃; for 0.333333h;

In water; at 20 ℃; for 0.25h; Further stages.;

DOI:10.1016/j.carres.2007.09.011

Reference yield:

5,5-dimethoxy-2-phenoxy-1,3,2-dioxaphosphorinane 2-oxide (231280-23-2) → phosphoric acid mono-(3-hydroxy-2,2-dimethoxy-propyl ester) (29909-09-9)

Guidance literature:

With barium dihydroxide; water;

DOI:10.1016/j.carres.2009.12.008

upstream raw materials:

O-phenyl phosphorodichloridate

2,2-dimethoxypropane-1,3-diol

Downstream raw materials:

cyclohexylamine

cyclohexylammonium 5,5-dimethoxy-2-oxo-1,3,2-dioxaphosphorinan-2-olate

phosphoric acid mono-(3-hydroxy-2,2-dimethoxy-propyl ester)

Refernces

• 1、 ?lepokura, Katarzyna,Lis, Tadeusz. "Dihydroxyacetone phosphate, DHAP, in the crystalline state: monomeric and dimeric forms". scheme or table. p. 512 - 529. Retrieved 2010/04/27.