10-deacetyl-9β-dihydrobaccatin III

Base Information

• Chemical Name: 10-deacetyl-9β-dihydrobaccatin III
• CAS No.: 162475-68-5
• Molecular Formula: C₂₉H₃₈O₁₀
• Molecular Weight: 546.615
• Mol file: 162475-68-5.mol

Synonyms:10-deacetyl-9β-dihydrobaccatin III

Chemical Property of 10-deacetyl-9β-dihydrobaccatin III

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-deacetyl-9β-dihydrobaccatin III

There total 2 articles about 10-deacetyl-9β-dihydrobaccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

10-deacetylbaccatin III (32981-86-5,172018-16-5) → 10-deacetyl-9β-dihydrobaccatin III (162475-68-5)

Guidance literature:

With samarium diiodide; acetic acid; In tetrahydrofuran; at -10 ℃; for 2h;

DOI:10.1021/jo981194s

Reference yield: 45.0%

10-deacetylbaccatin III (32981-86-5,172018-16-5) → 9β-dihydro-10-deacetoxybaccatin III + 10-deacetyl-9β-dihydrobaccatin III (162475-68-5)

Guidance literature:

With samarium diiodide; water; In tetrahydrofuran; at 25 ℃; for 3h;

DOI:10.1016/0040-4039(95)00142-Y

Reference yield: 75.9%

acrylaldehyde diethyl acetal (3054-95-3) + 10-deacetyl-9β-dihydrobaccatin III (162475-68-5) → 9β-10-deacetyl-9-dihydro-9,10-O-(2-allylidene)baccatin III (184586-22-9)

Guidance literature:

bis(cyclopentadienyl)titanium dichloride; In dichloromethane; at 24 - 28 ℃; for 18h;

upstream raw materials:

10-deacetylbaccatin III

Downstream raw materials:

9β-10-deacetyl-9-dihydro-9,10-O-(2-allylidene)baccatin III

10-deacetyl-7,10-bis TES-9β-dihydrobaccatin III

C₃₇H₄₄O₁₁

C₃₂H₄₂O₁₀

Refernces

• 1、 -. "Taxane Compounds, Compositions And Methods". Page/Page column 13. . Retrieved 2012/01/14.
• 2、 Ishiyama, Takashi,Iimura, Shin,Ohsuki, Satoru,Uoto, Kouichi,Terasawa, Hirofumi,Soga, Tsunehiko. "New highly active taxoids from 9β-Dihydrobaccatin-9,10-acetals". . p. 1083 - 1086. Retrieved 2007/10/03.