1H-Pyrazole-4-carboxylicacid, 3,5-dichloro-1-methyl-, methyl ester

Base Information

• Chemical Name: 1H-Pyrazole-4-carboxylicacid, 3,5-dichloro-1-methyl-, methyl ester
• CAS No.: 109056-69-1
• Molecular Formula: C6H6 Cl2 N2 O2
• Molecular Weight: 209.032
• Mol file: 109056-69-1.mol

Synonyms:3,5-Dichloro-1-methylpyrazole-4-(methoxycarbonyl)pyrazole;3,5-Dichloro-1-methylpyrazole-4-carboxylic acid methyl ester;3,5-Dichloro-4-(methoxycarbonyl)-1-methylpyrazole; Methyl3,5-dichloro-1-methylpyrazole-4-carboxylate

Chemical Property of 1H-Pyrazole-4-carboxylicacid, 3,5-dichloro-1-methyl-, methyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-4-carboxylicacid, 3,5-dichloro-1-methyl-, methyl ester

There total 1 articles about 1H-Pyrazole-4-carboxylicacid, 3,5-dichloro-1-methyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl ester of 1-methylpyrazole-4-carboxylic acid (5952-93-2) → Methyl 5-Chloro-1-methylpyrazole-4-carboxylate (88398-85-0) + methyl 3,5-dichloro-1-methyl-1H-pyrazole-4-carboxylate (109056-69-1)

Guidance literature:

With N-chloro-succinimide; at 120 ℃; Yield given. Yields of byproduct given;

DOI:10.1002/jhet.5570340231

Reference yield: 62.0%

2,4-dichlorobenzenethiol (1122-41-4) + methyl 3,5-dichloro-1-methyl-1H-pyrazole-4-carboxylate (109056-69-1) → methyl 3-chloro-5-(2,4-dichlorophenylthio)-1-methylpyrazole-4-carboxylate

Guidance literature:

In diethyl ether; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

methyl 3,5-dichloro-1-methyl-1H-pyrazole-4-carboxylate (109056-69-1) → 3-chloro-4-methoxycarbonyl-1-methylpyrazole-5-sulfonamide (100784-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / 70percent sodium hydrosulfide / dimethylformamide / 0.5 h / 60 °C

2: 1.) chlorine, aq. AcOH, 2.) 28percent aq. NH₃ / 1.) 5 deg C, 2.) 1,2-dichloroethane, RT, 0.5 h

With ammonium hydroxide; sodium hydrogensulfide; chlorine; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570340231

upstream raw materials:

methyl ester of 1-methylpyrazole-4-carboxylic acid

Downstream raw materials:

3-chloro-4-methoxycarbonyl-1-methylpyrazole-5-sulfonamide

halosulfuron methyl

Refernces