3-(2,2-diphenylethylsulfanylmethyl)-7-methoxybenzofuran

Base Information

• Chemical Name: 3-(2,2-diphenylethylsulfanylmethyl)-7-methoxybenzofuran
• CAS No.: 863911-51-7
• Molecular Formula: C₂₄H₂₂O₂S
• Molecular Weight: 374.503
• Mol file: 863911-51-7.mol

Synonyms:3-(2,2-diphenylethylsulfanylmethyl)-7-methoxybenzofuran

Chemical Property of 3-(2,2-diphenylethylsulfanylmethyl)-7-methoxybenzofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2,2-diphenylethylsulfanylmethyl)-7-methoxybenzofuran

There total 7 articles about 3-(2,2-diphenylethylsulfanylmethyl)-7-methoxybenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-chloromethyl-7-methoxybenzofuran (181052-53-9) + 1,1-diphenylethanethiol (71351-02-5) → 3-(2,2-diphenylethylsulfanylmethyl)-7-methoxybenzofuran (863911-51-7)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1021/jm050194z

Reference yield:

3-chloromethyl-7-methoxy-2,3-dihydro-benzofuran-3-ol → 3-(2,2-diphenylethylsulfanylmethyl)-7-methoxybenzofuran (863911-51-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.88 g / p-toluenesulfonic acid monohydrate / toluene / 2 h / 50 °C

2: 99 percent / t-BuOK / dimethylformamide / 1 h / 20 °C

With potassium tert-butylate; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm050194z

Reference yield:

2-(2,2-diphenylethylsulfanyl)benzoxazole (863911-82-4) → 3-(2,2-diphenylethylsulfanylmethyl)-7-methoxybenzofuran (863911-51-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / aq. NaOH / ethanol; tetrahydrofuran / 4 h / 40 °C

2: 90 percent / AcOH; Zn / 1 h / 90 °C

3: 99 percent / t-BuOK / dimethylformamide / 1 h / 20 °C

With sodium hydroxide; potassium tert-butylate; acetic acid; zinc; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm050194z

upstream raw materials:

3-chloromethyl-7-methoxybenzofuran

1,1-diphenylethanethiol

2-(2,2-diphenylethylsulfanyl)benzoxazole

di-(2,2-diphenylethyl) disulfide

Downstream raw materials:

[3-(2,2-diphenylethylsulfanylmethyl)benzofuran-7-yloxy]acetic acid methyl ester

3-(2,2-diphenylethylsulfanylmethyl)benzofuran-7-ol

Refernces