AKOS B006681

Base Information

• Chemical Name: AKOS B006681
• CAS No.: 1204-32-6
• Molecular Formula: C11H11 N O2
• Molecular Weight: 189.214
• Hs Code.: 2933990090
• Mol file: 1204-32-6.mol

Synonyms:Indole-6-carboxylicacid, 1-methyl-, methyl ester (7CI,8CI); 1-Methyl-1H-indole-6-carboxylic acidmethyl ester; Methyl 1-methyl-1H-indole-6-carboxylate

Chemical Property of AKOS B006681

Chemical Property:

• Vapor Pressure: 0.000323mmHg at 25°C
• Melting Point: 90～93℃
• Boiling Point: 320.2oC at 760 mmHg
• Flash Point: 147.4oC
• PSA: 31.23000
• Density: 1.14g/cm3
• LogP: 1.96490
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Methylindole-6-carboxylicacidmethylester 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AKOS B006681

There total 8 articles about AKOS B006681 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

indole-6-carboxylic acid methyl ester (50820-65-0) + methyl iodide (74-88-4) → methyl 1-methylindole-6-carboxylate (1204-32-6)

Guidance literature:

indole-6-carboxylic acid methyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield: 83.0%

→ methyl 1-methylindole-6-carboxylate (1204-32-6)

Guidance literature:

Reference yield:

Indole-6-carboxylic acid (1670-82-2,261352-47-0) + methyl iodide (74-88-4) → methyl 1-methylindole-6-carboxylate (1204-32-6)

Guidance literature:

In N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

indole-6-carboxylic acid methyl ester

methyl iodide

methyl chloroformate

6-bromo-1-methyl-1H-indole

Downstream raw materials:

6-(hydroxymethyl)-N-methylindole

methyl 1-methyl-3-phenyl-1H-indole-6-carboxylate

methyl 2-[(N,4-dimethylphenyl)sulfonamido]-1-methyl-1H-indole-6-carboxylate

Refernces

• 1、 Pu, Xingwen,Zhang, Mangang,Lan, Jingbo,Chen, Shuyou,Liu, Zheng,Liang, Wenbo,Yang, Yudong,Zhang, Min,You, Jingsong. "Tandem Rh(III)-Catalyzed C-H Heteroarylation of Indolyl Ketones and Cu(II)-Promoted Intramolecular Cyclization: One-Pot Access to Blue-Emitting Phenanthrone-Type Polyheterocycles". supporting information. p. 1139 - 1143. Retrieved 2019/05/16.
• 2、 -. "BETA-LACTAMASE INHIBITORS". Paragraph 0495. . Retrieved 2014/07/22.