N-tert-Butyl 4-Nitrophenylsulfonamide

Base Information

• Chemical Name: N-tert-Butyl 4-Nitrophenylsulfonamide
• CAS No.: 49690-09-7
• Molecular Formula: C10H14N2O4S
• Molecular Weight: 258.298
• Mol file: 49690-09-7.mol

Synonyms:N-tert-Butyl-4-nitrobenzenesulfonamide;

Chemical Property of N-tert-Butyl 4-Nitrophenylsulfonamide

Chemical Property:

• Vapor Pressure: 2.34E-06mmHg at 25°C
• Refractive Index: 1.545
• Boiling Point: 392.2 °C at 760 mmHg
• Flash Point: 191 °C
• Density: 1.282 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

N-tert-Butyl4-Nitrophenylsulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-tert-Butyl 4-Nitrophenylsulfonamide

There total 9 articles about N-tert-Butyl 4-Nitrophenylsulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

tert-butylamine (75-64-9) + 4-Nitrobenzenesulfonyl chloride (98-74-8) → N-dimethylethyl-4-nitrobenzenesulfonamide (49690-09-7)

Guidance literature:

tert-butylamine; 4-Nitrobenzenesulfonyl chloride; In tetrahydrofuran; at 20 ℃; for 24h;

With hydrogenchloride; In chloroform; water; Acidic aqueous solution;

Reference yield: 92.0%

4-aminobenzenesulfonyl chloride (24939-24-0) + tert-butylamine (75-64-9) → N-dimethylethyl-4-nitrobenzenesulfonamide (49690-09-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1021/acsmedchemlett.9b00243

Reference yield: 91.0%

→ N-dimethylethyl-4-nitrobenzenesulfonamide (49690-09-7)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 0.5h;

upstream raw materials:

tert-butylamine

4-Nitrobenzenesulfonyl chloride

methanesulfonic acid

ethyl N-tert-butyl-4-nitrobenzenesulfonimidate

Downstream raw materials:

ethyl N-tert-butyl-4-nitrobenzenesulfonimidate

N-(4-(tert-butylsulfamoyl)phenyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide

N-(4-(tert-butylsulfamoyl)phenyl)-3-methyl-D-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide

3-methyl-N-(4-sulfamoylphenyl)-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide

Refernces

• 1、 -. "BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS". Page/Page column 232-233; 234. . Retrieved 2017/05/02.
• 2、 Brueckner, Alexander C.,Hancock, Erin N.,Anders, Evan J.,Tierney, Matthew M.,Morgan, Heather R.,Scott, Kristina A.,Lamar, Angus A.. "Visible-light-mediated, nitrogen-centered radical amination of tertiary alkyl halides under metal-free conditions to form α-tertiary amines". supporting information. p. 4387 - 4392. Retrieved 2016/06/06.