3-(BENZYLOXY)CYCLOBUTANE-1,1-DICARBOXYLIC ACID

Base Information

• Chemical Name: 3-(BENZYLOXY)CYCLOBUTANE-1,1-DICARBOXYLIC ACID
• CAS No.: 84182-46-7
• Molecular Formula: C13H14O5
• Molecular Weight: 250.251
• Hs Code.: 2918990090
• Mol file: 84182-46-7.mol

Synonyms:1,1-Cyclobutanedicarboxylicacid, 3-(benzyloxy)- (6CI,7CI);3-(Phenylmethoxy)-1,1-cyclobutanedicarboxylic acid;3-(Benzyloxy)cyclobutane-1,1-dicarboxylic acid;

Chemical Property of 3-(BENZYLOXY)CYCLOBUTANE-1,1-DICARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 1.8E-09mmHg at 25°C
• Melting Point: ca 164℃
• Refractive Index: 1.595
• Boiling Point: 465.7 °C at 760 mmHg
• Flash Point: 181 °C
• PSA: 83.83000
• Density: 1.36 g/cm³
• LogP: 1.52120

Purity/Quality:

98%min ^*data from raw suppliers

3-Benzyloxycyclobutane-1,1-dicarboxylic acid Aldrich ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(BENZYLOXY)CYCLOBUTANE-1,1-DICARBOXYLIC ACID

There total 6 articles about 3-(BENZYLOXY)CYCLOBUTANE-1,1-DICARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

diethyl 3-(benzyloxy)cyclobutane-1,1-dicarboxylate (54166-15-3) → 3-(benzyloxy)cyclobutane-1,1-dicarboxylic acid (84182-46-7)

Guidance literature:

With potassium hydroxide; In ethanol; for 1.5h; Heating;

Reference yield:

C13H12O5(2-)*2K(1+) → 3-(benzyloxy)cyclobutane-1,1-dicarboxylic acid (84182-46-7)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 16 ℃; pH=2.5 - 3;

Reference yield:

1-bromo-2-benzyloxy-3-chloropropane (54307-67-4) → 3-(benzyloxy)cyclobutane-1,1-dicarboxylic acid (84182-46-7)

Guidance literature:

Multi-step reaction with 2 steps

2: aq. 4M KOH / H₂O; ethanol / 5 h / Heating

With potassium hydroxide; In ethanol; water;

DOI:10.1002/hlca.19920750216

upstream raw materials:

diethyl 3-(benzyloxy)cyclobutane-1,1-dicarboxylate

1-bromo-2-benzyloxy-3-chloropropane

benzyl bromide

Downstream raw materials:

3-amino-1-benzyloxycyclobutane

tert-butyl (3-(benzyloxy)cyclobutyl)carbamate

N-((1S,3S)-3-(benzyloxy)cyclobutyl)benzo[d]thiazol-2-amine

N-(2-aminophenyl)-3-(benzyloxy)cyclobutanecarboxamide

Refernces

• 1、 -. "HETEROARYLOXYCARBOCYCLYL COMPOUNDS AS PDE10 INHIBITORS". Page/Page column 43. . Retrieved 2011/12/02.
• 2、 -. "NOVEL INTERMEDIATES AND THEIR USE". Page/Page column 16-17. . Retrieved 2010/11/27.