ethyl 4H-furo[3,2-b]pyrrole-5-carboxylate

Base Information

• Chemical Name: ethyl 4H-furo[3,2-b]pyrrole-5-carboxylate
• CAS No.: 35405-94-8
• Molecular Formula: C9H9NO3
• Molecular Weight: 179.17
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID70508422
• Wikidata: Q82365313
• Mol file: 35405-94-8.mol

Synonyms:ethyl 4H-furo[3,2-b]pyrrole-5-carboxylate;35405-94-8;Ethyl furo[3,2-b]pyrrole-5-carboxylate;4h-furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester;NNABKJKQNGGLKM-UHFFFAOYSA;SCHEMBL1171015;NNABKJKQNGGLKM-UHFFFAOYSA-;AMY1917;DTXSID70508422;NNABKJKQNGGLKM-UHFFFAOYSA-N;AKOS000799900;BB 0254659;CS-0298962;ethyl 4H-furo[3,2-b] pyrrole-5-carboxylate;EN300-110113;F87934;4H-furo[2,3-d]pyrrole-5-carboxylic acid ethyl ester;F2158-1434;InChI=1/C9H9NO3/c1-2-12-9(11)7-5-8-6(10-7)3-4-13-8/h3-5,10H,2H2,1H3

Chemical Property of ethyl 4H-furo[3,2-b]pyrrole-5-carboxylate

Chemical Property:

• Boiling Point: 298.307 °C at 760 mmHg
• Flash Point: 134.212 °C
• PSA: 55.23000
• Density: 1.288 g/cm³
• LogP: 1.93760
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 179.058243149
• Heavy Atom Count: 13
• Complexity: 207

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl furo[3,2-b]pyrrole-5-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=CC2=C(N1)C=CO2

Technology Process of ethyl 4H-furo[3,2-b]pyrrole-5-carboxylate

There total 14 articles about ethyl 4H-furo[3,2-b]pyrrole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethyl 2-azido-3-(furan-2-yl)acrylate (35355-49-8) → 4H-Furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester (35405-94-8)

Guidance literature:

In toluene; for 2h; Inert atmosphere; Reflux;

DOI:10.1021/acs.jmedchem.7b00180

Reference yield: 91.0%

ethyl (Z)-2-azido-3-(2-furyl)prop-2-enoate → 4H-Furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester (35405-94-8)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; for 0.5h; Reflux;

DOI:10.1021/acs.jmedchem.6b01018

Reference yield: 70.0%

C16H14BrNO5 → 4H-Furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester (35405-94-8)

Guidance literature:

With cesium acetate; copper (I) acetate; In dimethyl sulfoxide; at 20 ℃; for 4h;

DOI:10.1021/op4001737

upstream raw materials:

ethyl 2-azido-3-(furan-2-yl)acrylate

C₁₆H₁₆BrNO₆

3-bromofurfural

ethyl 4-benzoyl-4H-furo[3,2-b]pyrrole-5-carboxylate

Downstream raw materials:

4-(4-Nitro-benzyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester

4-benzylfuro<3,2-b>pyrrole

4-benzylfuro<3,2-b>pyrrole-5-carboxylic acid

4-methylfuro[3,2-b]pyrrole-5-carboxylic acid

Refernces

• 1、 -. "PIKFYVE KINASE INHIBITORS". Page/Page column 142-143; 169-170. . Retrieved 2021/08/20.
• 2、 -. "PIKFYVE KINASE INHIBITORS". Page/Page column 43; 44. . Retrieved 2019/03/17.