4-(Tert-butyldiphenylsilyloxy)cyclohexanecarbonitrile

Base Information

• Chemical Name: 4-(Tert-butyldiphenylsilyloxy)cyclohexanecarbonitrile
• CAS No.: 141336-97-2
• Molecular Formula: C23H29NOSi
• Molecular Weight: 363.575
• DSSTox Substance ID: DTXSID30597251
• Mol file: 141336-97-2.mol

Synonyms:141336-97-2;4-(TERT-BUTYLDIPHENYLSILYLOXY)CYCLOHEXANECARBONITRILE;Cyclohexanecarbonitrile, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-;4-[tert-butyl(diphenyl)silyl]oxycyclohexane-1-carbonitrile;4-((tert-butyldiphenylsilyl)oxy)cyclohexane-1-carbonitrile;4-(tert-Butyldiphenylsilyloxy)-cyclohexanecarbonitrile;4-[(TERT-BUTYLDIPHENYLSILYL)OXY]CYCLOHEXANE-1-CARBONITRILE;FAXMLJQZLHERED-UHFFFAOYSA-N;3-Amino-2-hydroxyhexanoicacid;SCHEMBL1501359;DTXSID30597251;AKOS015904509;A807752;4-((tert-butyl(diphenyl)silyl)oxy)cyclohexanecarbonitrile;4-[tert-butyl(diphenyl)silyl]oxy-1-cyclohexanecarbonitrile;4-{[tert-Butyl(diphenyl)silyl]oxy}cyclohexane-1-carbonitrile;4-[[(1,1-Dimethylethyl)diphenylsilyl]oxy]cyclohexanecarbonitrile

Chemical Property of 4-(Tert-butyldiphenylsilyloxy)cyclohexanecarbonitrile

Chemical Property:

• Vapor Pressure: 2.39E-08mmHg at 25°C
• Refractive Index: 1.549
• Boiling Point: 451.7 °C at 760 mmHg
• Flash Point: 227 °C
• PSA: 33.02000
• Density: 1.04 g/cm³
• LogP: 4.64538
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 363.201841083
• Heavy Atom Count: 26
• Complexity: 464

Purity/Quality:

98% ^*data from raw suppliers

4-(tert-Butyldiphenylsilyloxy)-cyclohexanecarbonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)[Si](C1=CC=CC=C1)(C2=CC=CC=C2)OC3CCC(CC3)C#N

Technology Process of 4-(Tert-butyldiphenylsilyloxy)cyclohexanecarbonitrile

There total 2 articles about 4-(Tert-butyldiphenylsilyloxy)cyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.9%

1H-imidazole (288-32-4) + 4-hydroxycyclohexane-1-carbonitrile (24056-34-6) + tert-butylchlorodiphenylsilane (58479-61-1) → 4-[[(1,1-Dimethylethyl)diphenylsilyl]oxy]cyclohexanecarbonitrile (141336-97-2)

Guidance literature:

In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

4-((tert-butyl(diphenyl)silyl)oxy)cyclohexanecarboxamide (1010086-36-8) → 4-[[(1,1-Dimethylethyl)diphenylsilyl]oxy]cyclohexanecarbonitrile (141336-97-2)

Guidance literature:

4-((tert-butyl(diphenyl)silyl)oxy)cyclohexanecarboxamide; With oxalyl dichloride; In dichloromethane; dimethyl sulfoxide; at -78 ℃; for 0.25h;

With triethylamine; In dichloromethane; dimethyl sulfoxide; at -78 - 20 ℃; for 2h;

upstream raw materials:

4-((tert-butyl(diphenyl)silyl)oxy)cyclohexanecarboxamide

1H-imidazole

4-hydroxycyclohexane-1-carbonitrile

tert-butylchlorodiphenylsilane

Refernces

• 1、 -. "Substituted sulfonamides, process of preparation and medicines containing same". . . Retrieved 2008/06/13.