Tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate

Base Information Edit

Chemical Name:Tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate
CAS No.:211108-50-8
Molecular Formula:C10H16FNO3
Molecular Weight:217.24
Hs Code.:2933399990
European Community (EC) Number:694-808-6
DSSTox Substance ID:DTXSID00441752
Nikkaji Number:J2.162.703H
Mol file:211108-50-8.mol

Synonyms:TERT-BUTYL 3-FLUORO-4-OXOPIPERIDINE-1-CARBOXYLATE;211108-50-8;1-BOC-3-FLUORO-4-OXOPIPERIDINE;3-Fluoro-4-oxopiperidine-1-carboxylic acid tert-butyl ester;3-Fluoro-4-oxo-piperidine-1-carboxylic acid tert-butyl ester;MFCD10566554;C10H16FNO3;1-PIPERIDINECARBOXYLIC ACID, 3-FLUORO-4-OXO-, 1,1-DIMETHYLETHYL ESTER;tert-butyl 3-fluoro-4-oxo-1-piperidinecarboxylate;MFCD28010938;(S)-tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate;1-(tert-Butoxycarbonyl)-3-fluoro-4-piperidone;tert-butyl3-fluoro-4-oxopiperidine-1-carboxylate;tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate;SCHEMBL255933;N-Boc-3-fluoro-4-piperidinone;DTXSID00441752;JZNWQLLPLOQGOI-UHFFFAOYSA-N;BCP07877;BBL102671;STL556475;(R)-1-Boc-3-fluoropiperidin-4-one;1-BOC-3-FLUORO-4-PIPERIDONE;AKOS005145774;AC-8858;CS-W000521;PB13258;SB12772;SB21990;SS-4324;1-Boc-3-fluoro-4-oxopiperidine, 95%;SY015075;SY099047;1-tert-butoxycarbonyl-3-fluoro-4-piperidone;AM20090177;B4858;BB 0262706;FT-0660802;A26037;EN300-170891;AU-004/43508333;1-(tert-Butyloxycarbonyl)-3-fluoropiperidine-4-one;W-206596;(+/-)-tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate;3-Fluoro-4-oxo-1-piperidinecarboxylic Acid tert-Butyl Ester;tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate, AldrichCPR;4-Boc-Piperidinone,3-fluoro;3-Fluoro-4-boc- Piperidinone;tert-Butyl 3-fluoro-4-oxopiperidin-1-carboxylate;N-t-BOC-5-Fluoropiperidin-4-one;1-Boc-3-fluoro-4-piperidone

Suppliers and Price of Tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate
500mg
$ 90.00

TCI Chemical
1-(tert-Butoxycarbonyl)-3-fluoro-4-piperidone >97.0%(GC)
200mg
$ 59.00

TCI Chemical
1-(tert-Butoxycarbonyl)-3-fluoro-4-piperidone >97.0%(GC)
1g
$ 173.00

SynQuest Laboratories
N-Boc-5-fluoro-4-piperidone
25 g
$ 402.00

SynQuest Laboratories
N-Boc-5-fluoro-4-piperidone
1 g
$ 44.00

SynQuest Laboratories
N-Boc-5-fluoro-4-piperidone
5 g
$ 125.00

Sigma-Aldrich
1-Boc-3-fluoro-4-oxopiperidine 95%
250mg
$ 80.10

Sigma-Aldrich
tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate Aldrich
1g
$ 637.00

Medical Isotopes, Inc.
tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate 95+%
5 g
$ 870.00

Matrix Scientific
3-Fluoro-4-oxopiperidine-1-carboxylic acid tert-butyl ester 95%
1g
$ 24.00

Total 79 raw suppliers

Chemical Property of Tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate Edit

Chemical Property:

Vapor Pressure:0.002mmHg at 25°C
Melting Point:88-90℃
Refractive Index:1.466
Boiling Point:288.719 °C at 760 mmHg
PKA:-3.61±0.40(Predicted)
Flash Point:128.413 °C
PSA：46.61000
Density:1.152 g/cm³
LogP:1.47230
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:217.11142153
Heavy Atom Count:15
Complexity:272

Purity/Quality:

98%,99%, ^*data from raw suppliers

tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36-52

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(=O)C(C1)F

Technology Process of Tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate

There total 5 articles about Tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 211108-48-4
tert-butyl 4-[(trimethylsilyl)oxy]-3,6-dihydropyridine-1(2H)-carboxylate

: 211108-50-8
tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate

Guidance literature:: With Selectfluor; In acetonitrile; at 20 - 40 ℃; for 2.16h;

Reference yield: 87.0%

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 211108-50-8
tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate

Guidance literature:: N-tert-butyloxycarbonylpiperidin-4-one; With chloro-trimethyl-silane; triethylamine;

With Selectfluor;
DOI:10.1016/j.bmcl.2020.127625