2-ISOPROPYL-PIPERAZINE

Base Information

• Chemical Name: 2-ISOPROPYL-PIPERAZINE
• CAS No.: 84468-53-1
• Molecular Formula: C7H16N2
• Molecular Weight: 128.2153
• Hs Code.: 2933599090
• Mol file: 84468-53-1.mol

Synonyms:2-Isopropylpiperazine;133181-64-3 [RN];

Chemical Property of 2-ISOPROPYL-PIPERAZINE

Chemical Property:

• Boiling Point: 184.1 °C at 760 mmHg
• PKA: 9.21±0.40(Predicted)
• Flash Point: 64.6 °C
• PSA: 24.06000
• Density: 0.851 g/cm³
• LogP: 2.46540

Purity/Quality:

98%min ^*data from raw suppliers

2-Isopropyl-piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ISOPROPYL-PIPERAZINE

There total 9 articles about 2-ISOPROPYL-PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(S)-tert-butyl 2-isopropylpiperazine-1-carboxylate (674792-05-3,886766-25-2) → (S)-2-isopropylpiperazine (84468-53-1,133181-64-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; ethyl acetate; at 20 ℃; for 40h;

Reference yield: 86.5%

2-(1-methylethyl)pyrazine (29460-90-0) → 2-(S)-Isopropyl-piperazine (84468-53-1)

Guidance literature:

With palladium 10% on activated carbon; 2-(3-isopropylpiperazin-1-yl)quinazoline; In ethanol; for 48h; under 2585.81 Torr;

Reference yield: 86.0%

(2S)-isopropylpiperazine-3,6-dione (16944-60-8) → (S)-2-isopropylpiperazine (84468-53-1,133181-64-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 60 - 65 ℃; for 72h;

upstream raw materials:

3-isopropyl-piperazine-2,5-dione

2-(1-methylethyl)pyrazine

(2S)-isopropylpiperazine-3,6-dione

N-benzyloxycarbonylvalylglycine methyl ester

Downstream raw materials:

benzyl 3-isopropylpiperazine-1-carboxylate

N'-cyano-2-isopropyl-N-(o-tolyl)piperazine-1-carboximidamide

benzyl-4-(N'-cyano-N-o-tolylcarbamimidoyl)-3-isopropylpiperazine-1-carboxylate

N-(4-chlorophenyl)-3-isopropylpiperazine-1-carboxamide

Refernces

• 1、 -. "KINASE INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE". Page/Page column 12. . Retrieved 2009/03/07.
• 2、 -. "NOVEL COMPOUNDS". Page/Page column 142. . Retrieved 2008/12/06.