2-BROMO-1-CHLORO-4-IODOBENZENE

Base Information

• Chemical Name: 2-BROMO-1-CHLORO-4-IODOBENZENE
• CAS No.: 31928-46-8
• Molecular Formula: C6H3 Br Cl I
• Molecular Weight: 317.351
• Hs Code.: 2903999090
• Mol file: 31928-46-8.mol

Synonyms:Benzene,2-bromo-1-chloro-4-iodo;3-Bromo-4-chloroiodobenzene;2-Brom-4-iod-chlorbenzol;3-Bromo-4-chloro-1-iodobenzol;

Chemical Property of 2-BROMO-1-CHLORO-4-IODOBENZENE

Chemical Property:

• Boiling Point: 286.7±25.0 °C(Predicted)
• PSA: 0.00000
• Density: 2.272±0.06 g/cm3(Predicted)
• LogP: 3.70710
• Storage Temp.: Refrigerated.

Purity/Quality:

98%, ^*data from raw suppliers

2-Bromo-1-chloro-4-iodobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-1-CHLORO-4-IODOBENZENE

There total 2 articles about 2-BROMO-1-CHLORO-4-IODOBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-bromo-4-chloroaniline (823-54-1) → 2-bromo-1-chloro-4-iodobenzene (31928-46-8)

Guidance literature:

3-bromo-4-chloroaniline; With sulfuric acid; at 20 ℃; for 0.5h;

With sodium nitrite; In water; at -5 ℃;

With Oxalamide; potassium iodide; In water; ethyl acetate; at -5 ℃;

Reference yield:

3-bromo-4-chloronitrobenzene (16588-26-4) → 2-bromo-1-chloro-4-iodobenzene (31928-46-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonium chloride; iron / water; ethanol / 3 h / Reflux

2.1: sulfuric acid / 0.5 h / 20 °C

2.2: -5 °C

2.3: -5 °C

With sulfuric acid; iron; ammonium chloride; In ethanol; water;

Reference yield: 80.0%

2-bromo-1-chloro-4-iodobenzene (31928-46-8) + 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (761446-44-0) → 4-(3-bromo-4-chlorophenyl)-1-methyl-1H-pyrazole

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; for 4h; Microwave irradiation;

upstream raw materials:

3-bromo-4-chloronitrobenzene

3-bromo-4-chloroaniline

Downstream raw materials:

3-iodochlorobenzene

Refernces