3-AMINO-2-METHOXY-BENZOIC ACID METHYL ESTER

Base Information

• Chemical Name: 3-AMINO-2-METHOXY-BENZOIC ACID METHYL ESTER
• CAS No.: 5129-25-9
• Molecular Formula: C9H11 N O3
• Molecular Weight: 181.191
• Hs Code.: 2922509090
• Mol file: 5129-25-9.mol

Synonyms:o-Anisicacid, 3-amino-, methyl ester (7CI,8CI); Methyl 3-amino-2-methoxybenzoate

Chemical Property of 3-AMINO-2-METHOXY-BENZOIC ACID METHYL ESTER

Chemical Property:

• Boiling Point: 140 °C(Press: 0.01 Torr)
• PKA: 3.39±0.10(Predicted)
• PSA: 61.55000
• Density: 1.179±0.06 g/cm3(Predicted)
• LogP: 1.64520
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Methyl3-Amino-2-methoxybenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMINO-2-METHOXY-BENZOIC ACID METHYL ESTER

There total 4 articles about 3-AMINO-2-METHOXY-BENZOIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methoxy-3-nitro-benzoic acid methyl ester (90564-26-4) → 2-methoxy-3-methoxycarbonylaniline (5129-25-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 40 ℃; for 3h;

DOI:10.1021/ol801980h

Reference yield: 64.0%

2-methoxybenzoic acid methyl ester (606-45-1) → 2-methoxy-3-methoxycarbonylaniline (5129-25-9) + methyl 2-methoxy-5-aminobenzoate (22802-67-1)

Guidance literature:

2-methoxybenzoic acid methyl ester; With pyridine; trifluorormethanesulfonic acid; tetrabutylammonium tetrafluoroborate; In acetonitrile; at 25 ℃; Electrochemical reaction;

With piperidine; In acetonitrile; at 80 ℃; for 12h; Overall yield = 92 %; Electrochemical reaction;

DOI:10.1021/ja402083e

Reference yield:

2-hydroxy-3-nitro-benzoic acid methyl ester (22621-41-6) → 2-methoxy-3-methoxycarbonylaniline (5129-25-9)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; water; for 5.5h;

upstream raw materials:

2-hydroxy-3-nitro-benzoic acid methyl ester

2-methoxy-3-nitro-benzoic acid methyl ester

2-methoxybenzoic acid methyl ester

3-nitrosalicylic acid

Downstream raw materials:

C₁₈H₁₈FNO₄

methyl 3-{[(4-chlorophenyl)(methyl)amino]sulfonyl}-2-methoxybenzoate

methyl 2-methoxy-3-(2-methoxy-3-nitrobenzamido)benzoate

methyl 2-(methyloxy)-3-{[(2-propen-1-yloxy)carbonyl]amino}benzoate

Refernces

• 1、 -. "TYK2 INHIBITORS AND USES THEREOF". Paragraph 00743; 00744. . Retrieved 2018/05/15.
• 2、 Sun, Chang,Ren, Changliang,Wei, Yuchen,Qin, Bo,Zeng, Huaqiang. "Patterned recognition of amines and ammonium ions by a stimuli-responsive foldamer-based hexameric oligophenol host". . p. 5307 - 5309. Retrieved 2013/06/27.