Technology Process of E-(7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-[(3R,5S)-3,5-dihydroxy-hept-6-enoic acid])-N-methoxy-N-methyl-amide
There total 10 articles about E-(7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-[(3R,5S)-3,5-dihydroxy-hept-6-enoic acid])-N-methoxy-N-methyl-amide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride; water;
In
acetonitrile;
at 40 ℃;
for 15h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine / dichloromethane / 1 h / 0 - 5 °C
2.1: water; sodium hydroxide / methanol / 40 °C
2.2: pH 2 - 4
3.1: 1,1'-carbonyldiimidazole / ethyl acetate / 3 h / 0 - 30 °C
3.2: 20 - 25 °C
4.1: potassium carbonate / acetonitrile / 70 °C
4.2: 15 h / 0 - 25 °C
5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 - -10 °C
6.1: hydrogenchloride; water / acetonitrile / 15 h / 40 °C
With
hydrogenchloride; water; potassium carbonate; triethylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide; water / methanol / 40 °C
1.2: pH 2 - 4
2.1: 1,1'-carbonyldiimidazole / ethyl acetate / 3 h / 0 - 30 °C
2.2: 20 - 25 °C
3.1: potassium carbonate / acetonitrile / 70 °C
3.2: 15 h / 0 - 25 °C
4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 - -10 °C
5.1: hydrogenchloride; water / acetonitrile / 15 h / 40 °C
With
hydrogenchloride; water; potassium carbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; ethyl acetate; acetonitrile;