2,5-Dichloronicotinaldehyde

Base Information

• Chemical Name: 2,5-Dichloronicotinaldehyde
• CAS No.: 176433-49-1
• Molecular Formula: C6H3Cl2NO
• Molecular Weight: 176.002
• Hs Code.: 2933399090
• Mol file: 176433-49-1.mol

Synonyms:2,5-Dichloropyridine-3-carboxaldehyde;

Chemical Property of 2,5-Dichloronicotinaldehyde

Chemical Property:

• Vapor Pressure: 0.016mmHg at 25°C
• Melting Point: 89-92 °C
• Refractive Index: 1.608
• Boiling Point: 256.283 °C at 760 mmHg
• PKA: -3.75±0.10(Predicted)
• Flash Point: 108.796 °C
• PSA: 29.96000
• Density: 1.489 g/cm³
• LogP: 2.20090
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2,5-Dichloronicotinaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-43
• Safety Statements: 36/37-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-Dichloronicotinaldehyde

There total 1 articles about 2,5-Dichloronicotinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2,5-dichloropyridine-3-carbaldehyde (176433-49-1)

Guidance literature:

Reference yield: 52.0%

2,5-dichloropyridine-3-carbaldehyde (176433-49-1) + 1.4-dibromobenzene (106-37-6) → C12H8BrCl2NO

Guidance literature:

1.4-dibromobenzene; With n-butyllithium; In tetrahydrofuran; at -90 - -85 ℃; for 1h;

2,5-dichloropyridine-3-carbaldehyde; In tetrahydrofuran; at 20 ℃; for 3.5h;

Reference yield:

2,5-dichloropyridine-3-carbaldehyde (176433-49-1) + 1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-hydroxy-ethanone (478834-10-5) → 5-Chloro-2-{2-[4-(4-Fluoro-Benzyl)-(2R,5S)-2,5-Dimethyl-Piperazin-1-Yl]-2-Oxo-Ethoxy}-Pyridine-3-Carbaldehyde (519172-46-4)

Guidance literature:

In toluene; mineral oil;

Downstream raw materials:

4-chloro-trans-crotononitrile

5-Chloro-2-{2-[4-(4-Fluoro-Benzyl)-(2R,5S)-2,5-Dimethyl-Piperazin-1-Yl]-2-Oxo-Ethoxy}-Pyridine-3-Carbaldehyde

(2,5-dichloro-3-pyridinyl)methanol

5-chloro-3-(methoxymethyl)picolinic acid

Refernces

• 1、 -. "Process for the preparation of 2-halogenopyridinealdehydes and novel 2-halogenopyridinealdehydes". . . Retrieved 2008/06/13.