2-CHLORO-5-FLUORO-4-FORMYLPYRIDINE

Base Information

• Chemical Name: 2-CHLORO-5-FLUORO-4-FORMYLPYRIDINE
• CAS No.: 884494-54-6
• Molecular Formula: C6H3ClFNO
• Molecular Weight: 159.55
• Hs Code.: 2933399990
• Mol file: 884494-54-6.mol

Synonyms:2-Chloro-5-fluoroisonicotinaldehyde;

Chemical Property of 2-CHLORO-5-FLUORO-4-FORMYLPYRIDINE

Chemical Property:

• Vapor Pressure: 0.077mmHg at 25°C
• Refractive Index: 1.565
• Boiling Point: 227.542 °C at 760 mmHg
• Flash Point: 91.414 °C
• PSA: 29.96000
• Density: 1.444 g/cm³
• LogP: 1.68660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-chloro-5-fluoroisonicotinaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-5-FLUORO-4-FORMYLPYRIDINE

There total 1 articles about 2-CHLORO-5-FLUORO-4-FORMYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-chloro-5-fluoropyridine (31301-51-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-chloro-5-fluoroisonicotinaldehyde (884494-54-6)

Guidance literature:

2-chloro-5-fluoropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -60 ℃; for 2h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at -60 ℃; for 2h;

Reference yield:

2-chloro-5-fluoroisonicotinaldehyde (884494-54-6) → 2-chloro-5-fluoro-(S)-4-{-1-[(R)-1-(4-methoxyphenyl)ethyl]pyrrolidin-2-yl}pyridine (1005343-06-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: magnesium / iodine / tetrahydrofuran / 2 h / 20 °C

1.2: 2 h / -30 °C

1.3: Cooling with ice

2.1: Dess-Martin periodane / dichloromethane / 3 h / 20 °C

3.1: water / acetone / 3 h / 20 °C

4.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0.5 h / -78 °C

4.2: -78 - 20 °C

With water; sodium tris(acetoxy)borohydride; Dess-Martin periodane; magnesium; acetic acid; iodine; In tetrahydrofuran; dichloromethane; acetone;

Reference yield:

2-chloro-5-fluoroisonicotinaldehyde (884494-54-6) → (5-fluoro-(S)-4-{1-[(R)-1-(4-methoxyphenyl)ethyl]pyrrolidin-2-yl}pyridin-2-yl)-(4-fluorophenyl)methylamine (1005343-07-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: magnesium / iodine / tetrahydrofuran / 2 h / 20 °C

1.2: 2 h / -30 °C

1.3: Cooling with ice

2.1: Dess-Martin periodane / dichloromethane / 3 h / 20 °C

3.1: water / acetone / 3 h / 20 °C

4.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0.5 h / -78 °C

4.2: -78 - 20 °C

5.1: potassium tert-butylate; CyJohnPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 3 h / 85 °C

With potassium tert-butylate; water; sodium tris(acetoxy)borohydride; Dess-Martin periodane; magnesium; acetic acid; CyJohnPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iodine; In tetrahydrofuran; dichloromethane; acetone; toluene;

upstream raw materials:

2-chloro-5-fluoropyridine

N,N-dimethyl-formamide

Downstream raw materials:

2-chloro-5-fluoro-(S)-4-{-1-[(R)-1-(4-methoxyphenyl)ethyl]pyrrolidin-2-yl}pyridine

(5-fluoro-(S)-4-{1-[(R)-1-(4-methoxyphenyl)ethyl]pyrrolidin-2-yl}pyridin-2-yl)-(4-fluorophenyl)methylamine

Refernces

• 1、 -. "[...] compound and pest control agent". Paragraph 0132; 0133. . Retrieved 2019/05/23.