2-(4-Methoxyphenyl)-3-methylmorpholine

Base Information

• Chemical Name: 2-(4-Methoxyphenyl)-3-methylmorpholine
• CAS No.: 100369-95-7
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.272
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID20655910
• Mol file: 100369-95-7.mol

Synonyms:2-(4-METHOXYPHENYL)-3-METHYLMORPHOLINE;100369-95-7;2-(4-METHOXY-PHENYL)-3-METHYL-MORPHOLINE;2-(4-methoxyphenyl)-3-methyl-morpholine;SCHEMBL2599492;DTXSID20655910;BHRUEGUXZCYUBO-UHFFFAOYSA-N;AKOS009357973;FT-0765967;A800113

Chemical Property of 2-(4-Methoxyphenyl)-3-methylmorpholine

Chemical Property:

• Boiling Point: 327.4±37.0 °C at 760 mmHg
• Flash Point: 132.1±16.0 °C
• PSA: 30.49000
• Density: 1.0±0.1 g/cm³
• LogP: 2.07340
• Storage Temp.: 2-8°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 207.125928785
• Heavy Atom Count: 15
• Complexity: 190

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Methoxyphenyl)-3-methylmorpholine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1C(OCCN1)C2=CC=C(C=C2)OC
• Use Description: 2-(4-Methoxy-phenyl)-3-methyl-morpholine, a specific chemical compound, serves varied functions across different fields. In the pharmaceutical sector, it can act as a key building block for the synthesis of novel drugs and bioactive molecules, contributing to drug discovery and development efforts. In organic chemistry, this compound plays a vital role as a versatile reagent, facilitating various chemical reactions and enabling the creation of complex molecular structures for research and practical applications. Furthermore, in the field of materials science, it may be employed in the synthesis of specialized materials with unique properties. The compound's versatile applications in pharmaceuticals, chemistry, and materials science underscore its importance in driving innovation, scientific exploration, and practical solutions in these diverse domains.

Technology Process of 2-(4-Methoxyphenyl)-3-methylmorpholine

There total 2 articles about 2-(4-Methoxyphenyl)-3-methylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(4-methoxyphenyl)-5-methylmorpholin-3-one (947691-57-8) → 2-(4-methoxy-phenyl)-3-methyl-morpholine (100369-95-7)

Guidance literature:

6-(4-methoxyphenyl)-5-methylmorpholin-3-one; With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 3.16667h;

With methanol; In tetrahydrofuran;

Reference yield:

1-hydroxy-1-<(4-methoxy)-phenyl>-2-propanone (119341-75-2,120390-77-4,15482-29-8) + ethanolamine (141-43-5) → 2-(4-methoxy-phenyl)-3-methyl-morpholine (100369-95-7)

Guidance literature:

Multistep reaction; (i) H₂, PtO₂, EtOH, (ii) aq. HCl;

DOI:10.1021/jm00334a007

Reference yield:

4-bromo-6,7-dimethoxy cinnoline (879014-17-2) + 2-(4-methoxy-phenyl)-3-methyl-morpholine (100369-95-7) → 6,7-dimethoxy-4-[2-(4-methoxyphenyl)-3-methylmorpholin-4-yl]cinnoline

Guidance literature:

With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 55 ℃; for 24h;

upstream raw materials:

1-hydroxy-1-<(4-methoxy)-phenyl>-2-propanone

ethanolamine

6-(4-methoxyphenyl)-5-methylmorpholin-3-one

Downstream raw materials:

2-(4-methoxy-phenyl)-3-methyl-morpholin-4-ylamine

2-(4-methoxy-cyclohexyl)-3-methyl-morpholine

[2-(4-methoxy-cyclohexyl)-3-methyl-morpholin-4-yl]-(1-methyl-2-phenyl-ethyl)-amine

2-<4-Methoxy-phenyl>-3-methyl-4-<1-phenyl-propyl-(2)-amino>-morpholin

Refernces

• 1、 -. "CINNOLINE AND QUINAZOLINE DERIVATES AS PHOSPHODIESTERASE 10 INHIBITORS". Page/Page column 53. . Retrieved 2010/11/28.