ortho-chlorophenylmalonic acid

Base Information

• Chemical Name: ortho-chlorophenylmalonic acid
• CAS No.: 144616-14-8
• Molecular Formula: C₉H₇ClO₄
• Molecular Weight: 214.605
• Mol file: 144616-14-8.mol

Synonyms:ortho-chlorophenylmalonic acid

Chemical Property of ortho-chlorophenylmalonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ortho-chlorophenylmalonic acid

There total 3 articles about ortho-chlorophenylmalonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

dimethyl 2-(2-chlorophenyl)malonate (107855-59-4) → ortho-chlorophenylmalonic acid (144616-14-8)

Guidance literature:

dimethyl 2-(2-chlorophenyl)malonate; With potassium hydroxide; In methanol; for 5h; Heating / reflux;

With hydrogenchloride; at 0 ℃;

Reference yield:

phenylmagnesium bromide → ortho-chlorophenylmalonic acid (144616-14-8)

Guidance literature:

With diethyl ether; Einleiten von Kohlendioxid in das Reaktionsgemisch;

Reference yield:

→ ortho-chlorophenylmalonic acid (144616-14-8)

Guidance literature:

With water; sodium hydroxide; at 60 ℃; for 5h;

upstream raw materials:

dimethyl 2-(2-chlorophenyl)malonate

Downstream raw materials:

2'-chloro-benzeneacetic acid

2-(2-chlorophenyl)-2-chlorocarbonylketene

2-amino-(2-chlorophenyl)ethanoic acid

Refernces

• 1、 -. "2- and 2,5-substituted phenylketoenols". Page column 78. . Retrieved 2010/01/31.