1-(2-METHANESULFONYL-PHENYL)-PIPERAZINE DIHYDROCHLORIDE

Base Information

• Chemical Name: 1-(2-METHANESULFONYL-PHENYL)-PIPERAZINE DIHYDROCHLORIDE
• CAS No.: 916488-42-1
• Molecular Formula: C₁₁H₁₆N₂O₂S*2ClH
• Molecular Weight: 313.248
• Hs Code.: 2933599090
• Mol file: 916488-42-1.mol

Synonyms:1-(2-METHANESULFONYL-PHENYL)-PIPERAZINE DIHYDROCHLORIDE;1-[2-(Methylsulphonyl)phenyl]piperazine hydrochloride;1-(2-(methylsulfonyl)phenyl)piperazine hydrochloride;2-[Piperazin-1-yl]phenyl methyl sulphone hydrochloride;1-(2-Methanesulfonylphenyl)piperazine hydrochloride;-(2-METHANESULFONYL-PHENYL)-PIPERAZINE DIHYDROCHLORIDE

Chemical Property of 1-(2-METHANESULFONYL-PHENYL)-PIPERAZINE DIHYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 1.88E-09mmHg at 25°C
• Melting Point: 285-289 °C (decomp)
• Boiling Point: 475.9°C at 760 mmHg
• Flash Point: 241.6°C
• PSA: 57.79000
• LogP: 3.57830
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

1-[2-(Methylsulfonyl)phenyl]piperazine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-METHANESULFONYL-PHENYL)-PIPERAZINE DIHYDROCHLORIDE

There total 3 articles about 1-(2-METHANESULFONYL-PHENYL)-PIPERAZINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

4-[2-(methylsulfonyl)phenyl]piperazine-1-carbaldehyde (916488-41-0) → 1-[2-(methylsulfonyl)phenyl]piperazine dihydrochloride (916488-42-1)

Guidance literature:

With hydrogenchloride; In methanol; at 50 ℃; for 1h;

DOI:10.1016/j.bmc.2006.07.023

Reference yield:

2-fluorothioanisole (655-20-9) → 1-[2-(methylsulfonyl)phenyl]piperazine dihydrochloride (916488-42-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / hydrogen peroxide; acetic acid; sodium tungstate dihydrate / H₂O / 5 h / 80 °C

2: 88 percent / K₂CO₃ / dimethylsulfoxide / 15 h / 110 °C

3: 61 percent / HCl / methanol / 1 h / 50 °C

With hydrogenchloride; sodium tungstate; dihydrogen peroxide; potassium carbonate; acetic acid; In methanol; water; dimethyl sulfoxide;

DOI:10.1016/j.bmc.2006.07.023

Reference yield:

1-fluoro-2-(methylsulfonyl)benzene (654-47-7) → 1-[2-(methylsulfonyl)phenyl]piperazine dihydrochloride (916488-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / K₂CO₃ / dimethylsulfoxide / 15 h / 110 °C

2: 61 percent / HCl / methanol / 1 h / 50 °C

With hydrogenchloride; potassium carbonate; In methanol; dimethyl sulfoxide;

DOI:10.1016/j.bmc.2006.07.023

upstream raw materials:

4-[2-(methylsulfonyl)phenyl]piperazine-1-carbaldehyde

2-fluorothioanisole

1-fluoro-2-(methylsulfonyl)benzene

Refernces