1-Bromo-2-(2-ethoxyethoxy)ethane

Base Information

• Chemical Name: 1-Bromo-2-(2-ethoxyethoxy)ethane
• CAS No.: 54550-36-6
• Molecular Formula: C6H13 Br O2
• Molecular Weight: 197.072
• Hs Code.: 2909199090
• European Community (EC) Number: 676-519-7
• DSSTox Substance ID: DTXSID70426733
• Nikkaji Number: J27.107A
• Wikidata: Q72471557
• Mol file: 54550-36-6.mol

Synonyms:54550-36-6;1-Bromo-2-(2-ethoxyethoxy)ethane;2-(2-ETHOXYETHOXY)ETHYL BROMIDE;1-(2-bromoethoxy)-2-ethoxyEthane;1-Bromo-3,6-dioxaoctane;1-bromo-2-(2-ethoxy-ethoxy)-ethane;SCHEMBL1782203;2-(2-Ethoxyethoxy)ethylbromide;DTXSID70426733;UEDIWIFQWRXXJG-UHFFFAOYSA-N;1-(2-ethoxyethoxy)-2-bromoethane;1-ethoxy-2-(2-bromoethoxy)ethane;1-bromo 2-(2-ethoxyethoxy)-ethane;1-bromo-2-(2-ethoxyethoxy)-ethane;MFCD00051920;AKOS000163679;[beta-(beta-ethoxy)ethoxy]ethyl bromide;[beta-(beta-ethoxy)-ethoxy]ethyl bromide;AS-61167;2-(2-Ethoxyethoxy)ethyl bromide, tech grade;CS-0186317;FT-0608463;FT-0608464;D97193;EN300-7332931

Chemical Property of 1-Bromo-2-(2-ethoxyethoxy)ethane

Chemical Property:

• Vapor Pressure: 0.362mmHg at 25°C
• Refractive Index: 1.4530
• Boiling Point: 86-88°C 12mm
• Flash Point: 86-88°C/12mm
• PSA: 18.46000
• Density: 1.299
• LogP: 1.43440
• Water Solubility.: Not miscible with water.
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 196.00989
• Heavy Atom Count: 9
• Complexity: 50.3

Purity/Quality:

99% ^*data from raw suppliers

1-Bromo-2-(2-ethoxyethoxy)ethane 98% ^*data from reagent suppliers

Safty Information:

• Statements: 36/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOCCOCCBr
• Uses: 2-(2-Ethoxyethoxy)ethyl bromide is used as pharmaceutical intermediates.

Technology Process of 1-Bromo-2-(2-ethoxyethoxy)ethane

There total 3 articles about 1-Bromo-2-(2-ethoxyethoxy)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-(2-ethoxyethoxy)ethyl tosylate (54176-27-1) → 1-bromo-2-(2-ethoxyethoxy)ethane (54550-36-6)

Guidance literature:

With lithium bromide; In acetone; Reflux;

DOI:10.1016/j.tetlet.2009.07.002

Reference yield: 87.0%

ethoxyethoxyethanol (111-90-0) → 1-bromo-2-(2-ethoxyethoxy)ethane (54550-36-6)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1124/jpet.106.103556

Reference yield: 65.0%

diethylene glycol (111-46-6) → 1-bromo-2-(2-ethoxyethoxy)ethane (54550-36-6)

Guidance literature:

With phosphorus tribromide; In pyridine; for 12h;

upstream raw materials:

ethoxyethoxyethanol

diethylene glycol

2-(2-ethoxyethoxy)ethyl tosylate

Downstream raw materials:

2-(2-ethoxyethoxy)ethyl azide

9-[3,5-bis[3,5-bis(benzyloxy)benzyloxy]benzyl]-2,7-dibromo-9-[2-(2-ethoxy-ethoxy)ethyl]-9H-fluorene

2-<<5-<<2-(2-ethoxyethoxy)ethyl>amino>pentyl>thio>-4,5-diphenyl-1H-imidazole

N-<2-(2-ethoxyethoxy)ethyl>-5-<(4,5-diphenyl-1H-imidazol-2-yl)thio>pentanamide

Refernces

• 1、 Montani, Rosana S.,Hegguilustoy, Claudia M.,Del Rosso, Pablo G.,Donnio, Bertrand,Guillon, Daniel,Garay, Raúl O.. "4′-(2-(2-Ethoxyethoxy)ethoxy)biphenyl-4-carboxylic acid-a polar smectogen for amphipathic liquid crystals". scheme or table. p. 5231 - 5234. Retrieved 2009/12/06.
• 2、 Maduskuie, Thomas P.,Wilde, Richard G.,Billheimer, Jeffrey T.,Cromley, Debra A.,Germain, Sandra,et al.. "Design, Synthesis, and Structure-Activity Relationship Studies for a New Imidazole Series of J774 Macrophage Specific Acyl-CoA:Cholesterol Acyltransferase (ACAT) Inhibitors". . p. 1067 - 1083. Retrieved 2007/10/02.