4-TERT-BUTYLCYCLOHEXYLAMINE, CIS

Base Information

• Chemical Name: 4-TERT-BUTYLCYCLOHEXYLAMINE, CIS
• CAS No.: 2163-33-9
• Molecular Formula: C10H21N
• Molecular Weight: 155.283
• Hs Code.: 2921300090
• Mol file: 2163-33-9.mol

Synonyms:Cyclohexylamine,4-tert-butyl-, cis- (8CI);Cis-4-t-Butylcyclohexanamine;cis-1-Amino-4-tert-butylcyclohexane;cis-4-tert-Butyl-1-cyclohexanamine;cis-4-tert-Butylcyclohexanamine;

Chemical Property of 4-TERT-BUTYLCYCLOHEXYLAMINE, CIS

Chemical Property:

• Vapor Pressure: 0.369mmHg at 25°C
• Refractive Index: 1.46
• Boiling Point: 197.953 °C at 760 mmHg
• PKA: 10.58±0.70(Predicted)
• Flash Point: 51.316 °C
• PSA: 26.02000
• Density: 0.861 g/cm³
• LogP: 3.25030

Purity/Quality:

98%Min ^*data from raw suppliers

CIS-1-AMINO-4-TERT-BUTYLCYCLOHEXANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-TERT-BUTYLCYCLOHEXYLAMINE, CIS

There total 10 articles about 4-TERT-BUTYLCYCLOHEXYLAMINE, CIS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-tercbutyl-cyclohexanone (98-53-3) → cis-4-tert-butyl-cyclohexylamine (2163-33-9)

Guidance literature:

With chloro[N-[4-(dimethylamino)phenyl]-2-pyridinecarboxamidato](pentamethylcyclopentadienyl)iridium; ammonium formate; acetic acid; In methanol; at 80 ℃; for 4h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.9b01565

Reference yield:

4-tert-butylcyclohexanone oxime (4701-98-8) → cis-4-tert-butyl-cyclohexylamine (2163-33-9) + trans-4-t-butylcyclohexylamine (2163-34-0)

Guidance literature:

With sodium; In ethanol; Yield given; Heating;

DOI:10.1021/jo00168a009

Reference yield:

cis-4-t-butylcyclohexanecarboxylic acid (943-28-2) → cis-4-tert-butyl-cyclohexylamine (2163-33-9)

Guidance literature:

With sodium azide; sulfuric acid;

DOI:10.1021/ja01522a044

upstream raw materials:

cis-4-t-butylcyclohexanecarboxylic acid

4-tert-butylcyclohexanone oxime

4-tercbutyl-cyclohexanone

4'-t-butylacetophenone

Downstream raw materials:

cis-4-t-butyl-N,N-dimethylcyclohexylamine

trans-N-(4-tert-butylcyclohexyl)pyrrolidine

N-(4-tert-Butyl-cyclohexyl)-3,3-diphenyl-propionamide

N-(cis-4-tert.-Butylcyclohexyl)-sulfinylamin

Refernces

• 1、 Harrison, Justin R.,Sarkar, Sandipan,Hampton, Shahienaz,Riley, Jennifer,Stojanovski, Laste,Sahlberg, Christer,Appelqvist, Pia,Erath, Jessey,Mathan, Vinodhini,Rodriguez, Ana,Kaiser, Marcel,Pacanowska, Dolores Gonzalez,Read, Kevin D.,Johansson, Nils Gunnar,Gilbert, Ian H.. "Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease". . p. 3066 - 3089. Retrieved 2021/06/14.
• 2、 Tanaka, Kouichi,Miki, Takashi,Murata, Kunihiko,Yamaguchi, Ayumi,Kayaki, Yoshihito,Kuwata, Shigeki,Ikariya, Takao,Watanabe, Masahito. "Reductive amination of ketonic compounds catalyzed by Cp*Ir(III) complexes bearing a picolinamidato ligand". . p. 10962 - 10977. Retrieved 2019/09/03.