4-Fluoro-2-methylpyridine

Base Information

• Chemical Name: 4-Fluoro-2-methylpyridine
• CAS No.: 766-16-5
• Molecular Formula: C6H6 F N
• Molecular Weight: 111.119
• Hs Code.: 2933399090
• European Community (EC) Number: 828-289-6
• DSSTox Substance ID: DTXSID10376480
• Nikkaji Number: J651.683A
• Wikidata: Q72474905
• Mol file: 766-16-5.mol

Synonyms:4-fluoro-2-methylpyridine;766-16-5;4-Fluoro-2-picoline;MFCD04114145;2-Methyl-4-Fluoropyridine;SCHEMBL12443;4-fluoranyl-2-methyl-pyridine;DTXSID10376480;LEJYGRVERQVBLB-UHFFFAOYSA-N;AKOS005063649;AB17919;AM62455;CS-W005007;GS-6616;SY021351;A9709;FT-0646531;EN300-103099;A838769;J-515665;trans-4-(Carbobenzoxyamino)cyclohexanecarboxylicAcid

Chemical Property of 4-Fluoro-2-methylpyridine

Chemical Property:

• Vapor Pressure: 11.9mmHg at 25°C
• Refractive Index: 1.477
• Boiling Point: 130.3 °C at 760 mmHg
• PKA: 4.83±0.10(Predicted)
• Flash Point: 32.6 °C
• PSA: 12.89000
• Density: 1.077g/cm³
• LogP: 1.52910
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Sensitive.: Air Sensitive
• Water Solubility.: Slightly soluble in water.
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 111.048427358
• Heavy Atom Count: 8
• Complexity: 74.9

Purity/Quality:

99%min ^*data from raw suppliers

4-Fluoro-2-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=CC(=C1)F
• Uses: It is used in the correlations with and limitations of the α scale of solvent hydrogen bond donor acidities.

Technology Process of 4-Fluoro-2-methylpyridine

There total 2 articles about 4-Fluoro-2-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methyl-4-pyridinamine (18437-58-6) → para-fluoro-2-methylpyridine (766-16-5)

Guidance literature:

With tetrafluoroboric acid; sodium nitrite; at -10 ℃; Erwaermen der Reaktionsloesung auf 60grad;

Reference yield:

→ para-fluoro-2-methylpyridine (766-16-5)

Guidance literature:

aus 4-Amino-2-methyl-pyridin;

DOI:10.1139/v72-372

Reference yield: 95.0%

para-fluoro-2-methylpyridine (766-16-5) → 4-fluoro-2-methylpyridine 1-oxide (696-09-3)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 25 ℃; for 2h; Inert atmosphere;

upstream raw materials:

3-methyl-4-pyridinamine

Downstream raw materials:

4-fluoro-2-methylpyridine 1-oxide

4-(3-iodo-1H-pyrazol-1-yl)-2-methylpyridine

2-(bromomethyl)-4-fluoropyridine

2-Methyl-4-dimethylaminopyridin