Technology Process of 3-chloro-4-fluoro-2-hydroxybenzoic acid
There total 4 articles about 3-chloro-4-fluoro-2-hydroxybenzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1,3-dimethyl-2-imidazolidinone; sodium hydroxide;
at 140 ℃;
for 2h;
- Guidance literature:
-
2-chloro-1-fluoro-3-(methoxymethoxy)benzene;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -75 ℃;
for 6h;
carbon dioxide;
In
tetrahydrofuran; cyclohexane;
With
hydrogenchloride;
In
water;
pH=1;
DOI:10.1002/ejoc.200400895
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sec-BuLi / tetrahydrofuran; cyclohexane / 2 h / -75 °C
1.2: 83 percent / 1,1,2-trichloro-1,2,2-trifluoroethane / tetrahydrofuran; cyclohexane / 0.75 h / -75 °C
2.1: BuLi / tetrahydrofuran; hexane / 6 h / -75 °C
2.2: tetrahydrofuran; cyclohexane
2.3: 69 percent / HCl / H2O / pH 1
With
n-butyllithium; sec.-butyllithium;
In
tetrahydrofuran; hexane; cyclohexane;
DOI:10.1002/ejoc.200400895
