3-AMINO-4-ETHYLBENZOIC ACID

Base Information

• Chemical Name: 3-AMINO-4-ETHYLBENZOIC ACID
• CAS No.: 5129-23-7
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Hs Code.: 2922499990
• Mol file: 5129-23-7.mol

Synonyms:3-Amino-4-ethylbenzoicacid;

Chemical Property of 3-AMINO-4-ETHYLBENZOIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 149.4-149.7 °C(Solv: water (7732-18-5))
• Refractive Index: 1.601
• Boiling Point: 349.015 °C at 760 mmHg
• PKA: 4.52±0.10(Predicted)
• Flash Point: 164.878 °C
• PSA: 63.32000
• Density: 1.205 g/cm³
• LogP: 2.11060
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

3-amino-4-ethylbenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMINO-4-ETHYLBENZOIC ACID

There total 5 articles about 3-AMINO-4-ETHYLBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.6%

4-Ethyl-3-nitrobenzoic acid (103440-95-5) → 3-Amino-4-ethyl benzoic acid (5129-23-7)

Guidance literature:

With hydrogen; palladium/active carbon; In methanol; at 0 - 20 ℃; for 1h;

Reference yield:

3-nitro-4-vinylbenzoic acid (156098-55-4) → 3-Amino-4-ethyl benzoic acid (5129-23-7)

Guidance literature:

With palladium 10% on activated carbon; ammonium formate; In methanol; for 2h; Inert atmosphere; Reflux;

Reference yield:

p-ethylbenzoic acid (619-64-7) → 3-Amino-4-ethyl benzoic acid (5129-23-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; nitric acid / 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr

With sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; In methanol;

upstream raw materials:

4-Ethyl-3-nitrobenzoic acid

4-chloro-3-nitrobenzoate

3-nitro-4-vinylbenzoic acid

p-ethylbenzoic acid

Downstream raw materials:

4-ethyl-N,N-dimethyl-3-(1-methyl-1H-imidazo[ 4,5-c]pyridin-6-ylamino)benzamide

3-amino-4-ethyl-N,N-dimethylbenzamide

6-(methoxycarbonyl)-3-methyl-1H-indazole

Refernces

• 1、 -. "IMIDAZO [4, 5 -C] PYRIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES". . . Retrieved 2013/08/28.
• 2、 -. "Sulfonamide compounds and medicinal use thereof". Page column 80. . Retrieved 2010/02/04.