3,3-diphenylpropanoic acid N,N-diethylamide

Base Information

• Chemical Name: 3,3-diphenylpropanoic acid N,N-diethylamide
• CAS No.: 80467-87-4
• Molecular Formula: C₁₉H₂₃NO
• Molecular Weight: 281.398
• Mol file: 80467-87-4.mol

Synonyms:3,3-diphenylpropanoic acid N,N-diethylamide

Chemical Property of 3,3-diphenylpropanoic acid N,N-diethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,3-diphenylpropanoic acid N,N-diethylamide

There total 11 articles about 3,3-diphenylpropanoic acid N,N-diethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-N,N-diethyl-3-phenylacrylamide (27829-46-5) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 3,3-diphenylpropanoic acid N,N-diethylamide (80467-87-4)

Guidance literature:

With aluminium trichloride; at 25 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2004.03.067

Reference yield: 90.0%

N,N-diethylcinnamide (27829-46-5,84039-69-0,3680-04-4) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 3,3-diphenylpropanoic acid N,N-diethylamide (80467-87-4)

Guidance literature:

With trifluorormethanesulfonic acid; at 20 ℃; for 2h;

DOI:10.1016/j.tet.2014.11.033

Reference yield: 87.0%

N,N-diethyl-3-phenyl-2-propynamide (85241-00-5) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 3,3-diphenylpropanoic acid N,N-diethylamide (80467-87-4)

Guidance literature:

With aluminum (III) chloride; In cyclohexane; at 20 ℃; for 15h;

DOI:10.1016/j.tetlet.2015.09.026

upstream raw materials:

N,N-diethylcinnamide

diethyl ether

3-bromo-1,1-diphenylpropan-2-one

diethylamine

Refernces

• 1、 Zakusilo, Dmitry N.,Ryabukhin, Dmitry S.,Boyarskaya, Irina A.,Yuzikhin, Oleg S.,Vasilyev, Aleksander V.. "Tandem superelectrophilic hydroarylation of CC bond and carbonyl reduction in cinnamides: Synthetic rout to 3,3-diarylpropylamines, valuable pharmaceuticals". . p. 102 - 108. Retrieved 2015/02/02.
• 2、 Koltunov, Konstantin Yu.,Walspurger, Stéphane,Sommer, Jean. "Friedel-Crafts alkylation of benzene with α,β-unsaturated amides". . p. 3547 - 3549. Retrieved 2007/10/03.