Technology Process of methyl 3-(2-(2,2-dibromovinyl)phenyl)-1-tosyl-1H-indole-6-carboxylate
There total 4 articles about methyl 3-(2-(2,2-dibromovinyl)phenyl)-1-tosyl-1H-indole-6-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
carbon tetrabromide; methyl 3-(2-formylphenyl)-1-tosyl-1H-indole-6-carboxylate;
In
dichloromethane;
at 0 ℃;
Inert atmosphere;
With
triisopropyl phosphite;
In
dichloromethane;
at 0 ℃;
for 0.5h;
Inert atmosphere;
DOI:10.1016/j.tet.2013.01.001
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: bis(dibenzylideneacetone)-palladium(0); triphenylphosphine; cesium fluoride / 1,2-dimethoxyethane / 17 h / 90 °C / Inert atmosphere
2.1: dichloromethane / 0 °C / Inert atmosphere
2.2: 0.5 h / 0 °C / Inert atmosphere
With
triphenylphosphine; cesium fluoride; bis(dibenzylideneacetone)-palladium(0);
In
1,2-dimethoxyethane; dichloromethane;
1.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.tet.2013.01.001
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane / 1.5 h / 20 °C / Inert atmosphere
2.1: bis(dibenzylideneacetone)-palladium(0); triphenylphosphine; cesium fluoride / 1,2-dimethoxyethane / 17 h / 90 °C / Inert atmosphere
3.1: dichloromethane / 0 °C / Inert atmosphere
3.2: 0.5 h / 0 °C / Inert atmosphere
With
tetra(n-butyl)ammonium hydrogensulfate; triphenylphosphine; cesium fluoride; potassium hydroxide; bis(dibenzylideneacetone)-palladium(0);
In
1,2-dimethoxyethane; dichloromethane;
2.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.tet.2013.01.001