4-Acetyl-4'-propylbiphenyl

Base Information

• Chemical Name: 4-Acetyl-4'-propylbiphenyl
• CAS No.: 60137-92-0
• Molecular Formula: C17H18O
• Molecular Weight: 238.32
• European Community (EC) Number: 435-610-1
• DSSTox Substance ID: DTXSID50394562
• Nikkaji Number: J3.213.316I
• Wikidata: Q82194022
• Mol file: 60137-92-0.mol

Synonyms:4-ACETYL-4'-PROPYLBIPHENYL;60137-92-0;1-[4-(4-propylphenyl)phenyl]ethanone;1-(4'-Propylbiphenyl-4-yl)ethanone;1-(4'-Propyl-biphenyl-4-yl)ethanone;1-{4'-propyl-[1,1'-biphenyl]-4-yl}ethan-1-one;SCHEMBL9406602;DTXSID50394562;MFCD00859438;AKOS006212721;1-(4'-Propyl-biphenyl-4-yl)-ethanone;FT-0640663;A832610;1-(4'-Propyl[1,1'-biphenyl]-4-yl)ethan-1-one

Chemical Property of 4-Acetyl-4'-propylbiphenyl

Chemical Property:

• Boiling Point: 365.1 °C at 760 mmHg
• Flash Point: 156.9 °C
• PSA: 17.07000
• Density: 1.011 g/cm³
• LogP: 4.50870
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 238.135765193
• Heavy Atom Count: 18
• Complexity: 255

Purity/Quality:

98%Min ^*data from raw suppliers

1-(4'-Propyl-biphenyl-4-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)C

Technology Process of 4-Acetyl-4'-propylbiphenyl

There total 3 articles about 4-Acetyl-4'-propylbiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-ethenyl-4'-propyl-1,1'-biphenyl (360768-57-6) → 1-(4'-propyl-[1,1'-biphenyl]-4-yl)ethanone (60137-92-0)

Guidance literature:

With silver tetrafluoroborate; water; In acetic acid; at 110 ℃; for 10h; regioselective reaction;

DOI:10.1016/j.tet.2013.05.057

Reference yield: 92.0%

para-bromoacetophenone (99-90-1) + 4-propylphenylboric acid (134150-01-9) → 1-(4'-propyl-[1,1'-biphenyl]-4-yl)ethanone (60137-92-0)

Guidance literature:

With C₂₀H₁₂N₂O₈PdS₂^(2-)*2Na⁽¹⁺⁾; sodium hydroxide; In water; at 100 ℃; for 6h;

DOI:10.1016/j.tet.2015.08.070

Reference yield:

4-propyl-1,1'-biphenyl (10289-45-9) + acetyl chloride (75-36-5) → 1-(4'-propyl-[1,1'-biphenyl]-4-yl)ethanone (60137-92-0)

Guidance literature:

With aluminium trichloride;

upstream raw materials:

4-propyl-1,1'-biphenyl

acetyl chloride

4-ethenyl-4'-propyl-1,1'-biphenyl

para-bromoacetophenone

Refernces

• 1、 Chen, Zheng-Wang,Ye, Dong-Nai,Qian, Yi-Ping,Ye, Min,Liu, Liang-Xian. "Highly efficient AgBF4-catalyzed synthesis of methyl ketones from terminal alkynes". . p. 6116 - 6120. Retrieved 2013/07/25.