3-(2-NAPHTHYL)-L-ALANINE BENZYL ESTER 4-TOLUENESULFONATE SALT

Base Information

• Chemical Name: 3-(2-NAPHTHYL)-L-ALANINE BENZYL ESTER 4-TOLUENESULFONATE SALT
• CAS No.: 126829-54-7
• Molecular Formula: C₂₀H₁₉NO₂
• Molecular Weight: 305.376
• Mol file: 126829-54-7.mol

Synonyms:3-(2-NAPHTHYL)-L-ALANINE BENZYL ESTER 4-TOLUENESULFONATE SALT;H-2-NAL-OBZL P-TOSYLATE SALT;H-2-NAL-OBZL TOS;H-ALA(2-NAPHTHYL)-OBZL TOSOH;H-ALA-2-NAL-OBZL TOSOH;H-ALA(2-NAPH)-OBZL TOS;H-2-Nal-OBzl

Chemical Property of 3-(2-NAPHTHYL)-L-ALANINE BENZYL ESTER 4-TOLUENESULFONATE SALT

Chemical Property:

• Boiling Point: 470.2±30.0 °C(Predicted)
• PKA: 6.97±0.33(Predicted)
• PSA: 115.07000
• Density: 1.185±0.06 g/cm3(Predicted)
• LogP: 6.47580
• Storage Temp.: Store at RT.

Purity/Quality:

98%Min ^*data from raw suppliers

3-(2-Naphthyl)-L-alaninebenzylester4-toluenesulfonatesalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-NAPHTHYL)-L-ALANINE BENZYL ESTER 4-TOLUENESULFONATE SALT

There total 7 articles about 3-(2-NAPHTHYL)-L-ALANINE BENZYL ESTER 4-TOLUENESULFONATE SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 3-(naphthalen-2-yl)-2-nitropropanoate → benzyl 3-(2-naphthyl)-2-aminopropionate (126829-54-7)

Guidance literature:

With zinc; In acetic acid; at 20 ℃; for 16.5h; Schlenk technique; Inert atmosphere;

DOI:10.1021/ol5028199

Reference yield:

benzyl phenyl carbonate (28170-07-2) → benzyl 3-(2-naphthyl)-2-aminopropionate (126829-54-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / dimethyl sulfoxide / 8.5 h / 60 °C / Inert atmosphere; Schlenk technique

2: zinc / acetic acid / 16.5 h / 20 °C / Schlenk technique; Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; zinc; In acetic acid; dimethyl sulfoxide;

DOI:10.1021/ol5028199

Reference yield:

2-(2-nitroethyl)naphthalene (115149-31-0) → benzyl 3-(2-naphthyl)-2-aminopropionate (126829-54-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / dimethyl sulfoxide / 8.5 h / 60 °C / Inert atmosphere; Schlenk technique

2: zinc / acetic acid / 16.5 h / 20 °C / Schlenk technique; Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; zinc; In acetic acid; dimethyl sulfoxide;

DOI:10.1021/ol5028199

upstream raw materials:

benzyl phenyl carbonate

2-(2-nitroethyl)naphthalene

β-naphthaldehyde

2-(2-nitrovinyl)naphthalene

Refernces

• 1、 -. "FUSED TRICYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY". . . Retrieved 2008/06/13.