Technology Process of (2R,3S)-3-(4-Methoxy-benzyloxy)-5-methyl-1-triisopropylsilanyloxy-hex-5-en-2-ol
There total 7 articles about (2R,3S)-3-(4-Methoxy-benzyloxy)-5-methyl-1-triisopropylsilanyloxy-hex-5-en-2-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
titanium(IV) isopropylate; butyl magnesium bromide;
In
diethyl ether;
at 0 ℃;
DOI:10.1021/ol051543m
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium periodate; buffer / CH2Cl2 / 0 - 20 °C / pH 4
2.1: TiCl4; (-)-sparteine / CH2Cl2 / 1 h / -78 °C
2.2: CH2Cl2 / 0.5 h / -78 °C
2.3: 0.128 g / lithium borohydride / diethyl ether; methanol; tetrahydrofuran / 1 h / 0 °C
3.1: 95 percent / imidazole / dimethylformamide / 15 h / 20 °C
4.1: 86 percent / sodium hydride / dimethylformamide; various solvent(s) / 0 - 20 °C
5.1: 86 percent / Ti(Oi-Pr)4; n-BuMgCl / diethyl ether / 0 °C
With
1H-imidazole; titanium(IV) isopropylate; sodium periodate; butyl magnesium bromide; titanium tetrachloride; sodium hydride; (-)-sparteine;
In
diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol051543m
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 95 percent / imidazole / dimethylformamide / 15 h / 20 °C
2: 86 percent / sodium hydride / dimethylformamide; various solvent(s) / 0 - 20 °C
3: 86 percent / Ti(Oi-Pr)4; n-BuMgCl / diethyl ether / 0 °C
With
1H-imidazole; titanium(IV) isopropylate; butyl magnesium bromide; sodium hydride;
In
diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/ol051543m