6-Hydroxy-5-nitro-2-picoline

Base Information

• Chemical Name: 6-Hydroxy-5-nitro-2-picoline
• CAS No.: 39745-39-6
• Molecular Formula: C6H6N2O3
• Molecular Weight: 154.125
• Hs Code.: 29337900
• Mol file: 39745-39-6.mol

Synonyms:2-Hydroxy-3-nitro-6-methylpyridine;2-Hydroxy-6-methyl-3-nitropyridine;6-Methyl-3-nitro-2-pyridinol;6-Methyl-3-nitro-2-pyridone;

Chemical Property of 6-Hydroxy-5-nitro-2-picoline

Chemical Property:

• Appearance/Colour: Yellow crystalline powder
• Vapor Pressure: 2.97E-05mmHg at 25°C
• Melting Point: 225-226 °C
• Refractive Index: 1.567
• Boiling Point: 356.2 °C at 760 mmHg
• PKA: 8.47±0.10(Predicted)
• Flash Point: 169.2 °C
• PSA: 78.94000
• Density: 1.36 g/cm³
• LogP: 1.52700
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Hydroxy-6-methyl-3-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 37/39-26-36-39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 6-Hydroxy-5-nitro-2-picoline

There total 12 articles about 6-Hydroxy-5-nitro-2-picoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

6-amino-5-nitro-2-picoline (21901-29-1) → 6-methyl-3-nitrohydropyridin-2-one (39745-39-6)

Guidance literature:

With sulfuric acid; water; sodium nitrite; at 0 ℃; for 16h;

Reference yield: 58.0%

1,3-dinitroquinolizin-4-one (1556-32-7) + acetone (67-64-1) → 6-methyl-3-nitropyridin-2-one (39745-39-6)

Guidance literature:

With ammonium acetate; In methanol; at 65 ℃; for 48h;

DOI:10.3987/com-01-9258

Reference yield: 32.0%

6-amino-5-nitro-2-picoline (21901-29-1) → 6-methyl-3-nitropyridin-2-one (39745-39-6)

Guidance literature:

With sodium nitrite;

DOI:10.3390/molecules25071682

upstream raw materials:

6-hydroxy-2-methylpyridine

2-chloro-6-methyl-3-nitropyridine

6-amino-5-nitro-2-picoline

ethyl 2-amino-6-methylnicotinate

Downstream raw materials:

2-hydroxy-6-methyl-3-aminopyridine

2-bromo-6-methyl-3-nitropyridine

2-chloro-6-methyl-3-nitropyridine

6-methyl-2-piperidyl-3-pyridylamine

Refernces

• 1、 -. "THE NITROPYRIDINYL ETHYLENEIMINE COMPOUND, THE PHARMACEUTICAL COMPOSITION CONTAINING IT, THE PREPARATION METHOD AND USE THEREOF". Page/Page column 11. . Retrieved 2011/10/10.
• 2、 Norman,Chen,Chen,Fotsch,Hale,Han,Hurt,Jenkins,Kincaid,Liu,Lu,Moreno,Santora,Sonnenberg,Karbon. "Structure-activity relationships of a series of pyrrolo[3,2-d]pyrimidine derivatives and related compounds as neuropeptide Y5 receptor antagonists". . p. 4288 - 4312. Retrieved 2007/10/03.