H-Arg(Z)2-OH

Base Information

• Chemical Name: H-Arg(Z)2-OH
• CAS No.: 4125-79-5
• Molecular Formula: C22H26N4O6
• Molecular Weight: 442.46500
• Hs Code.: 2925290090
• Mol file: 4125-79-5.mol

Synonyms:NG,NG,-Di-Cbz-L-arginine;H-Arg(Z)2-OH;

Chemical Property of H-Arg(Z)2-OH

Chemical Property:

• PSA: 159.32000
• LogP: 3.49640
• Storage Temp.: −20°C

Purity/Quality:

98%Min ^*data from raw suppliers

Nω,Nω-Di-Z-L-arginine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-Arg(Z)2-OH

There total 4 articles about H-Arg(Z)2-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Nα-tert-butoxycarbonyl-Nδ,Nω-di-benzyloxycarbonyl-L-arginine (51219-19-3) → H-Arg(Z)2-OH (4125-79-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1002/ejoc.200800591

Reference yield:

Nα,Nδ,Nω-tris(benzyloxycarbonyl)-L-arginine (14611-34-8) → H-Arg(Z)2-OH (4125-79-5)

Guidance literature:

With thionyl chloride; Behandeln einer Loesung des Reaktionsprodukts in Aceton mit konz. wss. HCl;

DOI:10.1021/jo01362a052

Reference yield:

L-arginine (74-79-3,25212-18-4) → H-Arg(Z)2-OH (4125-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorocarbonic acid benzyl ester; aqueous NaOH / Reinigung ueber das Natrium-Salz

2: SOCl₂ / Behandeln einer Loesung des Reaktionsprodukts in Aceton mit konz. wss. HCl

With sodium hydroxide; thionyl chloride; benzyl chloroformate;

DOI:10.1021/jo01362a052

upstream raw materials:

N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginine

L-arginine

N^α-tert-butoxycarbonyl-N^δ,N^ω-di-benzyloxycarbonyl-L-arginine

Downstream raw materials:

N^α-Fmoc-N^δ,N^ε-Z₂-Arg

N-Boc-Tyr(Bn)-Arg(Z)2-OH

N-Boc-Tyr(Bn)-Arg(Z)rTrp-NH(4-OH)Ph

N-Boc-Tyr(Bn)-Arg(Z)2-Trp-NHCH₂Ph

Refernces

• 1、 Roche, Stephane P.,Faure, Sophie,El Blidi, Lahssen,Aitken, David J.. "Total synthesis of cyclotheonamide C by use of an α-keto cyanophosphorane methodology for peptide assembly". experimental part. p. 5067 - 5078. Retrieved 2009/05/07.