1-bromo-2,3,4-trifluoro-5-iodobenzene

Base Information

• Chemical Name: 1-bromo-2,3,4-trifluoro-5-iodobenzene
• CAS No.: 530145-57-4
• Molecular Formula: C₆HBrF₃I
• Molecular Weight: 336.878
• Mol file: 530145-57-4.mol

Synonyms:1-bromo-2,3,4-trifluoro-5-iodobenzene

Chemical Property of 1-bromo-2,3,4-trifluoro-5-iodobenzene

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-bromo-2,3,4-trifluoro-5-iodobenzene

There total 3 articles about 1-bromo-2,3,4-trifluoro-5-iodobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-bromo-2,3,4-trifluorobenzene (176317-02-5) → 1-bromo-2,3,4-trifluoro-5-iodobenzene (530145-57-4)

Guidance literature:

With n-butyllithium; iodine; diisopropylamine; In tetrahydrofuran; hexane; at -75 ℃; for 2h;

DOI:10.1002/ejoc.200390078

Reference yield: 89.0%

(5-bromo-2,3,4-trifluorophenyl)triethylsilane (530145-56-3) → 1-bromo-2,3,4-trifluoro-5-iodobenzene (530145-57-4)

Guidance literature:

With Iodine monochloride; In tetrachloromethane; for 36h; Heating;

DOI:10.1002/ejoc.200390078

Reference yield:

1,2,3-trifluorobenzene (1489-53-8) → 1-bromo-2,3,4-trifluoro-5-iodobenzene (530145-57-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / sec-butyllithium; bromine / tetrahydrofuran; cyclohexane / 45 h / -75 °C

2: 92 percent / diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C

3: 89 percent / iodine monochloride / CCl₄ / 36 h / Heating

With n-butyllithium; bromine; sec.-butyllithium; Iodine monochloride; diisopropylamine; In tetrahydrofuran; tetrachloromethane; hexane; cyclohexane;

DOI:10.1002/ejoc.200390078

upstream raw materials:

1-bromo-2,3,4-trifluorobenzene

(5-bromo-2,3,4-trifluorophenyl)triethylsilane

1,2,3-trifluorobenzene

Downstream raw materials:

methyl 3-bromo-4,5,6-trifluorobenzoate

2-bromo-3,4,5-trifluoro-1-iodobenzene

3-bromo-4,5,6-trifluorobenzoic acid

Refernces