2,2-bis(4-chloro-benzyl)-1,3-propanediol

Base Information

• Chemical Name: 2,2-bis(4-chloro-benzyl)-1,3-propanediol
• CAS No.: 1046446-22-3
• Molecular Formula: C₁₇H₁₈Cl₂O₂
• Molecular Weight: 325.235
• Mol file: 1046446-22-3.mol

Synonyms:2,2-bis(4-chloro-benzyl)-1,3-propanediol

Chemical Property of 2,2-bis(4-chloro-benzyl)-1,3-propanediol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-bis(4-chloro-benzyl)-1,3-propanediol

There total 3 articles about 2,2-bis(4-chloro-benzyl)-1,3-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

diethyl bis(4-chloro-benzyl) malonate (7012-60-4) → 2,2-bis(4-chloro-benzyl)-1,3-propanediol (1046446-22-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; Reagent/catalyst; Temperature; Inert atmosphere;

Reference yield:

Bis-(4-chlor-benzyl)-malonsaeuredimethylester (2172-48-7) → 2,2-bis(4-chloro-benzyl)-1,3-propanediol (1046446-22-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 1.5h; Heating;

DOI:10.1016/j.tet.2008.05.081

Reference yield:

1-Chloro-4-(chloromethyl)benzene (104-83-6) → 2,2-bis(4-chloro-benzyl)-1,3-propanediol (1046446-22-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / toluene; dichloromethane

2: lithium borohydride; ammonium sulfate / water

With ammonium sulfate; lithium borohydride; potassium carbonate; In dichloromethane; water; toluene;

upstream raw materials:

Bis-(4-chlor-benzyl)-malonsaeuredimethylester

diethyl bis(4-chloro-benzyl) malonate

1-Chloro-4-(chloromethyl)benzene

Downstream raw materials:

C₁₇H₁₆Cl₂I₂

C₁₇H₁₆Br₂Cl₂

C₁₇H₁₆Cl₄

Refernces

• 1、 -. "COMPLIMENTARY POLYMER ELECTROCHROMIC DEVICE". Page/Page column. . Retrieved 2013/05/22.