(1S,4R)-4-AMinocyclopent-2-enecarboxylic acid hydrochloride

Base Information

• Chemical Name: (1S,4R)-4-AMinocyclopent-2-enecarboxylic acid hydrochloride
• CAS No.: 130931-84-9
• Molecular Formula: C6H10ClNO2
• Molecular Weight: 163.604
• Mol file: 130931-84-9.mol

Synonyms:2-Cyclopentene-1-carboxylicacid, 4-amino-, hydrochloride, (1S,4R)- (9CI);2-Cyclopentene-1-carboxylicacid, 4-amino-, hydrochloride, (1S-cis)-;(1S,4R)-4-Aminocyclopent-2-ene-1-carboxylic acid hydrochloride;

Chemical Property of (1S,4R)-4-AMinocyclopent-2-enecarboxylic acid hydrochloride

Chemical Property:

• PSA: 63.32000
• LogP: 1.47670
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(1S,4R)-4-Amino-2-cyclopenten-1-carboxylicAcidHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,4R)-4-AMinocyclopent-2-enecarboxylic acid hydrochloride

There total 5 articles about (1S,4R)-4-AMinocyclopent-2-enecarboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(-)-2-azabicyclo[2.2.1]hept-5-en-3-one (79200-56-9) → (-)-(1S,4R)-4-aminocyclopent-2-ene-1-carboxylic acid hydrochloride (130931-84-9)

Guidance literature:

With hydrogenchloride;

Reference yield: 79.0%

(1S-cis)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic acid (151907-79-8,108999-93-5) → (-)-(1S,4R)-4-aminocyclopent-2-ene-1-carboxylic acid hydrochloride (130931-84-9)

Guidance literature:

With hydrogenchloride; In ethanol;

DOI:10.1002/ejoc.200800723

Reference yield:

→ 2-azabicyclo[2.2.1.]hept-5-en-3-one (49805-30-3) + (-)-(1S,4R)-4-aminocyclopent-2-ene-1-carboxylic acid hydrochloride (130931-84-9)

Guidance literature:

upstream raw materials:

(-)-2-azabicyclo[2.2.1]hept-5-en-3-one

(–)-methyl (1S,4R)-4-aminocyclopent-2-ene-1-carboxylate hydrochloride

(1S-cis)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-cyclopentene-1-carboxylic acid

Refernces

• 1、 Forro, Eniko,Fueloep, Ferenc. "Enzymatic method for the synthesis of blockbuster drug intermediates - Synthesis of five-membered cyclic γ-amino acid and γ-lactam enantiomers". experimental part. p. 5263 - 5268. Retrieved 2009/06/18.
• 2、 Evans, Chris T.,Roberts, Stanley M.,Shoberu, Karoline A.,Sutherland, Alan G.. "Potential Use of Carbocyclic Nucleosides for the Treatment of AIDS: Chemo-enzymatic Syntheses of the Enantiomers of Carbovir". . p. 589 - 592. Retrieved 2007/10/02.