3-AMINO-BUTAN-1-OL

Base Information

• Chemical Name: 3-AMINO-BUTAN-1-OL
• CAS No.: 2867-59-6
• Molecular Formula: C4H11NO
• Molecular Weight: 89.1374
• Hs Code.: 2922199090
• Mol file: 2867-59-6.mol

Synonyms:2-Amino-4-hydroxybutane;3-Amino-3-methylpropan-1-ol;3-Aminobutanol;

Chemical Property of 3-AMINO-BUTAN-1-OL

Chemical Property:

• Vapor Pressure: 0.531mmHg at 25°C
• Melting Point: 8.72°C (estimate)
• Refractive Index: 1.446
• Boiling Point: 168.349 °C at 760 mmHg
• PKA: 15.00±0.10(Predicted)
• Flash Point: 55.616 °C
• PSA: 46.25000
• Density: 0.927 g/cm³
• LogP: 0.41630
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: Dichloromethane, DMSO

Purity/Quality:

99.0% ^*data from raw suppliers

3-Aminobutan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (R)-3-Aminobutan-1-ol, can be used as an intermediate in the preparation of compounds having HIV integrase inhibitory activity.

Technology Process of 3-AMINO-BUTAN-1-OL

There total 12 articles about 3-AMINO-BUTAN-1-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-aminobutyric acid (2835-82-7) → 2-aminobutanol (2867-59-6)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 ℃; for 23.33h; Heating / reflux;

Reference yield: 93.0%

4-hydroxy-2-butanone oxime (42875-72-9) → 2-aminobutanol (2867-59-6)

Guidance literature:

With hydrogen; In methanol; at 45 ℃; for 28h; under 7500.75 Torr; Autoclave;

DOI:10.1021/acs.oprd.1c00139

Reference yield: 90.0%

2-(4-hydroxybutan-2-yl)-isoindoline-1,3-dione (126121-40-2,545376-10-1) → 2-aminobutanol (2867-59-6)

Guidance literature:

With hydrazine; In ethanol; for 3h; Reflux;

DOI:10.1021/ja902591g

upstream raw materials:

3-aminobutyric acid

3-aminobutanoic acid ethyl ester

1-Hydroxy-3-butanone

5-ethoxy-3-methyl-4,5-dihydro-isoxazole

Downstream raw materials:

2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

N-(4-hydroxybutan-2-yl)-4-methylbenzenesulfonamide

(R)-4-hydroxybutan-2-aminium (S)-2-hydroxy-2-phenylacetate

3,6-dimethyl-2-phenylpyridine

Refernces

• 1、 Sch?nenberger,Vogel,Bamann. "On the production of new local anesthetically effective compounds". . p. 371 - 378. Retrieved 1965.
• 2、 -. "Refining process of R-3-amino n-butyl alcohol". Paragraph 0018-0021; 0032-0040. . Retrieved 2021/04/07.
• 3、 Han, Sang-Woo,Shin, Jong-Shik. "Rapid and Quantitative Profiling of Substrate Specificity of ω-Transaminases for Ketones". . p. 3287 - 3295. Retrieved 2019/06/21.