2,3-Dichloro-6-methoxyquinoxaline

Base Information

• Chemical Name: 2,3-Dichloro-6-methoxyquinoxaline
• CAS No.: 39267-04-4
• Molecular Formula: C9H6Cl2N2O
• Molecular Weight: 229.065
• Hs Code.: 2933990090
• European Community (EC) Number: 806-741-3
• DSSTox Substance ID: DTXSID30350621
• Wikidata: Q72466720
• Mol file: 39267-04-4.mol

Synonyms:2,3-dichloro-6-methoxyquinoxaline;39267-04-4;2,3-Dichloro-6-methoxy-quinoxaline;Quinoxaline, 2,3-dichloro-6-methoxy-;Quinoxaline,2,3-dichloro-6-methoxy-;SCHEMBL1160610;DTXSID30350621;AMY14257;BCP23951;CS-M2334;2,3-di-chloro-6-methoxyquinoxaline;MFCD00461063;STK728062;AKOS000447386;AC-28947;DS-15786;A6578;FT-0609544;SR-01000435538;SR-01000435538-1

Chemical Property of 2,3-Dichloro-6-methoxyquinoxaline

Chemical Property:

• Vapor Pressure: 0.00096mmHg at 25°C
• Refractive Index: 1.637
• Boiling Point: 312.6 °C at 760 mmHg
• Flash Point: 142.9 °C
• PSA: 35.01000
• Density: 1.451 g/cm³
• LogP: 2.94520
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 227.9857182
• Heavy Atom Count: 14
• Complexity: 205

Purity/Quality:

98%, ^*data from raw suppliers

2,3-Dichloro-6-methoxyquinoxaline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)N=C(C(=N2)Cl)Cl
• Uses: 2,3-Dichloro-6-methoxyquinoxaline is used for preparation of antibacterial and antifungal activity of (tetrazolo[1,5-a]quinoxalinyl)dihydrophthalazine-diones as reactant or reagent.

Technology Process of 2,3-Dichloro-6-methoxyquinoxaline

There total 18 articles about 2,3-Dichloro-6-methoxyquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.5%

2,3-dihydroxy-6-methoxyquinoxaline (31910-18-6) → 2,3-dichloro-6-methoxyquinoxaline (39267-04-4)

Guidance literature:

With acetyl chloride; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 93.1%

2,3-dioxo-6-methoxy-1,2,3,4-tetrahydroquinoxaline (31910-18-6) → 2,3-dichloro-6-methoxyquinoxaline (39267-04-4)

Guidance literature:

With trichlorophosphate; for 24h; Reflux;

Reference yield: 11.0%

methanol (67-56-1) + 2,3-dioxo-6-methoxy-1,2,3,4-tetrahydroquinoxaline (31910-18-6) → 2,3-dichloro-6-methoxyquinoxaline (39267-04-4) + 1,4-dimethyl-2,3-dioxo-6-methoxy-1,2,3,4-tetrahydroquinoxaline (60729-19-3) + 3-chloro-7-methoxy-1-methylquinoxalin-2(1H)-one (263715-90-8)

Guidance literature:

methanol; 2,3-dioxo-6-methoxy-1,2,3,4-tetrahydroquinoxaline; With sodium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

With thionyl chloride; In 1,4-dioxane; N,N-dimethyl-formamide; at 90 ℃; for 3h;

DOI:10.3987/COM-99-S61

upstream raw materials:

2,3-dioxo-6-methoxy-1,2,3,4-tetrahydroquinoxaline

2,3-dihydroxy-6-methoxyquinoxaline

methanol

glyoxylic acid ethyl ester

Downstream raw materials:

methyl (1aR,5S,8S,10R,22aR)-5-tert-butyl-14-methoxy-3,6-dioxo-18,19-didehydro-1,1a,3,4,5,6,9,10,20,21,22,22a-dodecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3, 6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylate

methyl (4R)-4-[(3-chloro-7-methoxyquinoxalin-2-yl)oxy]-L-prolinate hydrochloride

(2S,4R)-4-[(3-chloro-7-methoxyquinoxalin-2-yl)oxy]-2-(methoxycarbonyl)pyrrolidin-1-ium methanesulfonate

Refernces

• 1、 -. "Novel molecular targeting anti-tumor aza-steroid derivative based on lipid toxicity and preparation and application thereof". Paragraph 0178; 0180; 0192; 0205; 0224. . Retrieved 2021/08/19.
• 2、 -. "NS3/4A protease inhibitor intermediate as well as synthesis method and application thereof". Paragraph 0034-0054; 0076; 0079; 0080; 0083; 0084; 0087. . Retrieved 2020/04/22.