4-Chloro-7-methoxyindoline-2,3-dione

Base Information

• Chemical Name: 4-Chloro-7-methoxyindoline-2,3-dione
• CAS No.: 60706-07-2
• Molecular Formula: C9H6ClNO3
• Molecular Weight: 211.60
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID10500900
• Wikidata: Q72453141
• Mol file: 60706-07-2.mol

Synonyms:60706-07-2;4-Chloro-7-methoxyindoline-2,3-dione;4-Chloro-7-methoxy isatin;4-Chloro-7-methoxyisatin;4-Chloro-7-methoxy-1H-indole-2,3-dione;4-chloro-7-methoxy-2,3-dihydro-1H-indole-2,3-dione;SCHEMBL1571412;DTXSID10500900;VZPMNHWRRJFLFO-UHFFFAOYSA-N;MFCD00047215;AKOS000142578;SB65264;AC-23026;FT-0689862;EN300-213918;Z247609676;(6S,8S,9S,10S,11S,13S,14S,16S,17R)-6,9-DIFLUORO-11,17-DIHYDROXY-17-(2-HYDROXYACETYL)-10,13,16-TRIMETHYL-6,7,8,11,12,14,15,16-OCTAHYDROCYCLOPENTA[A]PHENANTHREN-3-ONE

Chemical Property of 4-Chloro-7-methoxyindoline-2,3-dione

Chemical Property:

• Refractive Index: 1.598
• PSA: 55.40000
• Density: 1.474 g/cm³
• LogP: 1.62140
• Storage Temp.: 2-8°C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 211.0036207
• Heavy Atom Count: 14
• Complexity: 281

Purity/Quality:

98%min ^*data from raw suppliers

4-Chloro-7-methoxyisatin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C2C(=C(C=C1)Cl)C(=O)C(=O)N2

Technology Process of 4-Chloro-7-methoxyindoline-2,3-dione

There total 3 articles about 4-Chloro-7-methoxyindoline-2,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

hydroxyimino-acetic acid-(5-chloro-2-methoxy-anilide) (67303-24-6,1081822-31-2) → 4-chloro-7-methoxyindoline-2,3-dione (60706-07-2)

Guidance literature:

With sulfuric acid; at 80 - 95 ℃; Verduennen des Reaktionsgemisches mit Wasser;

Reference yield:

5-chloro-2-methoxyaniline (95-03-4) → 4-chloro-7-methoxyindoline-2,3-dione (60706-07-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; hydroxylamine sulfate

2: concentrated sulfuric acid / 80 - 95 °C / Verduennen des Reaktionsgemisches mit Wasser

With sulfuric acid; hydroxylamine sulfate;

Reference yield:

→ 4-chloro-7-methoxyindoline-2,3-dione (60706-07-2)

Guidance literature:

entspr. Anisidid 6, H2SO4;

upstream raw materials:

hydroxyimino-acetic acid-(5-chloro-2-methoxy-anilide)

5-chloro-2-methoxyaniline

Downstream raw materials:

5,6-bis(4-fluorophenyl)-8-hydroxyquinazolin-4(3H)-one

5,6-bis(4-fluorophenyl)-8-methoxyquinazolin-4(3H)-one

4,5-bis(4-fluorophenyl)-7-methoxyindoline-2,3-dione

C₁₈H₁₃ClN₄O₄S