Ethyl 2-(2,4-difluorophenyl)-6-chloronicotinate

Base Information

• Chemical Name: Ethyl 2-(2,4-difluorophenyl)-6-chloronicotinate
• CAS No.: 745833-19-6
• Molecular Formula: C₁₄H₁₀ClF₂NO₂
• Molecular Weight: 297.689
• Mol file: 745833-19-6.mol

Synonyms:Ethyl 2-(2,4-difluorophenyl)-6-chloronicotinate;

Chemical Property of Ethyl 2-(2,4-difluorophenyl)-6-chloronicotinate

Chemical Property:

• Refractive Index: 1.543
• Boiling Point: 371.4 °C at 760 mmHg
• Flash Point: 178.4 °C
• PSA: 39.19000
• Density: 1.336 g/cm³
• LogP: 3.85690
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl 2-(2,4-difluorophenyl)-6-chloronicotinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2-(2,4-difluorophenyl)-6-chloronicotinate

There total 1 articles about Ethyl 2-(2,4-difluorophenyl)-6-chloronicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-(2,4-difluorophenyl)-3-(ethoxycarbonyl)pyridine 1-oxide (1219503-90-8) → 6-chloro-2-(2,4-difluorophenyl)nicotinic acid ethyl ester (745833-19-6)

Guidance literature:

With trichlorophosphate; In 1,2-dichloro-ethane; at 21 - 75 ℃; Product distribution / selectivity;

upstream raw materials:

2-(2,4-difluorophenyl)-3-(ethoxycarbonyl)pyridine 1-oxide

Refernces

• 1、 -. "PROCESSES FOR PRODUCING PHENYL-6-(1-(PHENYL)UREIDO)NICOTINAMIDES)". Page/Page column 23-24. . Retrieved 2010/09/03.