2-(Piperidin-4-yl)ethanamine

Base Information

• Chemical Name: 2-(Piperidin-4-yl)ethanamine
• CAS No.: 76025-62-2
• Molecular Formula: C7H16N2
• Molecular Weight: 128.217
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID70363730
• Nikkaji Number: J2.348.861B
• Wikidata: Q72500392
• Mol file: 76025-62-2.mol

Synonyms:2-(Piperidin-4-yl)ethanamine;76025-62-2;4-Piperidineethanamine;2-piperidin-4-ylethanamine;2-(piperidin-4-yl)ethan-1-amine;4-(2-AMINOETHYL)PIPERIDINE;Piperidine-4-ethaneamine;SCHEMBL331464;Piperidine, 4-(2-aminoethyl);DTXSID70363730;BDA02562;AKOS010394508;SB42139;AM101244;BS-29599;FT-0689825;EN300-64907;Z756921054

Chemical Property of 2-(Piperidin-4-yl)ethanamine

Chemical Property:

• Boiling Point: 198.6 °C at 760 mmHg
• PKA: 10.61±0.10(Predicted)
• Flash Point: 82.7 °C
• PSA: 38.05000
• Density: 0.892 g/cm³
• LogP: 1.36390
• Storage Temp.: 2-8°C
• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 128.131348519
• Heavy Atom Count: 9
• Complexity: 67.3

Purity/Quality:

99% ^*data from raw suppliers

2-(Piperidin-4-yl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1CCN

Technology Process of 2-(Piperidin-4-yl)ethanamine

There total 3 articles about 2-(Piperidin-4-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C16H19NO2 → 2-(piperidin-4-yl)ethanamine (76025-62-2)

Guidance literature:

With hydrazine hydrate; In ethanol; at 80 ℃; for 4h; Solvent; Concentration; Temperature; Reflux;

Reference yield: 68.0%

→ 2-(piperidin-4-yl)ethanamine (76025-62-2)

Guidance literature:

Reference yield:

4-(2-chloroethyl)-piperidine (114998-55-9) → 2-(piperidin-4-yl)ethanamine (76025-62-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 8 h / 65 °C

2: hydrazine hydrate / ethanol / 4 h / 80 °C / Reflux

With potassium carbonate; hydrazine hydrate; In ethanol; acetone;

upstream raw materials:

4-(2-chloroethyl)-piperidine

Downstream raw materials:

1-[3β-(4-chlorophenyl)tropane-2β-carbonylamino]-2-[1-[3β-(4-chlorophenyl)tropane-2β-carbonyl]piperidin-4-yl]ethane

2-[4-(2-amino-ethyl)-piperidin-1-yl]-6-(3-chloro-phenyl-amino)-9-ethyl-9H-purine

C₁₉H₂₆N₆O₃S

Refernces

• 1、 -. "Amino alcohol derivatives, process for their production and pharmaceutical preparations and reagents containing these compounds". Page 9. . Retrieved 2008/06/13.