Technology Process of (1S,2S,3R,4R)-1-amino-3,4-di-O-benzyl-5-(benzyloxymethyl)cyclohex-5-ene-2,3,4-triol
There total 29 articles about (1S,2S,3R,4R)-1-amino-3,4-di-O-benzyl-5-(benzyloxymethyl)cyclohex-5-ene-2,3,4-triol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triphenylphosphine;
In
pyridine; ammonium hydroxide;
Ambient temperature;
DOI:10.1021/jo982024i
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 85 percent / NaH, Bu4NI / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temp., overnight
2: 70 percent / SOCl2, pyridine / CH2Cl2 / 5.5 h / 0 °C
3: 85 percent / CF3COOH, H2O / CH2Cl2 / 24 h / Ambient temperature
4: 95 percent / SOCl2, Et3N / CH2Cl2 / 1 h / 0 °C
5: 90 percent / LiN3 / dimethylformamide / 3 h / 80 °C
6: 95 percent / pyridine / CH2Cl2 / 3 h / 0 °C
7: 27 percent / dimethylformamide / 80 °C
8: 100 percent / K2CO3 / methanol / 12 h / Ambient temperature
9: 97 percent / PPh3 / pyridine; aq. NH3 / Ambient temperature
With
pyridine; thionyl chloride; lithium azide; water; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid;
In
tetrahydrofuran; pyridine; methanol; ammonium hydroxide; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo982024i
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 85 percent / NaH, Bu4NI / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temp., overnight
2: 70 percent / SOCl2, pyridine / CH2Cl2 / 5.5 h / 0 °C
3: 85 percent / CF3COOH, H2O / CH2Cl2 / 24 h / Ambient temperature
4: 95 percent / SOCl2, Et3N / CH2Cl2 / 1 h / 0 °C
5: 90 percent / LiN3 / dimethylformamide / 3 h / 80 °C
6: 95 percent / pyridine / CH2Cl2 / 3 h / 0 °C
7: 27 percent / dimethylformamide / 80 °C
8: 100 percent / K2CO3 / methanol / 12 h / Ambient temperature
9: 97 percent / PPh3 / pyridine; aq. NH3 / Ambient temperature
With
pyridine; thionyl chloride; lithium azide; water; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid;
In
tetrahydrofuran; pyridine; methanol; ammonium hydroxide; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo982024i