C₉H₉BrFNO

Base Information

• Chemical Name: C₉H₉BrFNO
• CAS No.: 195390-25-1
• Molecular Formula: C₉H₉BrFNO
• Molecular Weight: 246.079
• Mol file: 195390-25-1.mol

Synonyms:C₉H₉BrFNO

Chemical Property of C₉H₉BrFNO

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₉H₉BrFNO

There total 1 articles about C₉H₉BrFNO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

meta-fluoroaniline (372-19-0) + 3-Bromopropionyl chloride (15486-96-1) → C9H9BrFNO (195390-25-1)

Guidance literature:

With potassium carbonate; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

C9H9BrFNO (195390-25-1) → C9H8FNO (1281991-43-2)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; for 2h;

Reference yield:

C9H9BrFNO (195390-25-1) → 7-fluoro-2,3-dihydro-1H-quinolin-4-one (114417-35-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium t-butanolate / N,N-dimethyl-formamide / 2 h / 20 °C

2: trifluorormethanesulfonic acid / 1,2-dichloro-ethane

With trifluorormethanesulfonic acid; sodium t-butanolate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; 2: Fries rearrangement;

DOI:10.1016/j.bmcl.2011.01.056

upstream raw materials:

meta-fluoroaniline

3-Bromopropionyl chloride

Downstream raw materials:

C₉H₈FNO

C₉H₉FN₄O

7-fluoro-2,3-dihydro-1H-quinolin-4-one

Refernces

• 1、 Zhou, Bo,He, Yantao,Zhang, Xian,Xu, Jie,Luo, Yong,Wang, Yuehong,Franzblau, Scott G.,Yang, Zhenyun,Chan, Rebecca J.,Liu, Yan,Zheng, Jianyu,Zhang, Zhong-Yin. "Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents". scheme or table. p. 4573 - 4578. Retrieved 2010/10/03.