TERT-BUTYL N-BENZYL-N-(PIPERIDIN-4-YL)CARBAMATE

Base Information

• Chemical Name: TERT-BUTYL N-BENZYL-N-(PIPERIDIN-4-YL)CARBAMATE
• CAS No.: 934695-78-0
• Molecular Formula: C₁₇H₂₆N₂O₂
• Molecular Weight: 290.406
• Hs Code.: 2933399090
• Mol file: 934695-78-0.mol

Synonyms:tert-Butyl N-benzyl-N-(piperidin-4-yl)carbamate;tert-butyl N-benzyl-N-(4-piperidyl)carbamate;

Chemical Property of TERT-BUTYL N-BENZYL-N-(PIPERIDIN-4-YL)CARBAMATE

Chemical Property:

• Boiling Point: 405.413 °C at 760 mmHg
• Flash Point: 198.987 °C
• PSA: 41.57000
• Density: 1.076 g/cm³
• LogP: 3.50450

Purity/Quality:

99% ^*data from raw suppliers

TERT-BUTYL-N-BENZYL-N-(PIPERIDIN-4-YL)CARBAMATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL N-BENZYL-N-(PIPERIDIN-4-YL)CARBAMATE

There total 4 articles about TERT-BUTYL N-BENZYL-N-(PIPERIDIN-4-YL)CARBAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(benzyl-tert-butoxycarbonyl-amino)-piperidine-1-carboxylic acid ethyl ester → benzyl-piperidin-4-yl-carbamic acid tert-butyl ester (934695-78-0)

Guidance literature:

With potassium hydroxide; In ethanol; water; Heating;

DOI:10.1016/j.bmcl.2006.12.096

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → benzyl-piperidin-4-yl-carbamic acid tert-butyl ester (934695-78-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran; H₂O / Heating

2: KOH / ethanol; H₂O / Heating

With potassium hydroxide; In tetrahydrofuran; ethanol; water;

DOI:10.1016/j.bmcl.2006.12.096

Reference yield:

ethyl 4-aminopiperidine-1-carboxylate (58859-46-4) → benzyl-piperidin-4-yl-carbamic acid tert-butyl ester (934695-78-0)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / 20 °C

2: tetrahydrofuran; H₂O / Heating

3: KOH / ethanol; H₂O / Heating

With potassium hydroxide; potassium carbonate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.12.096

upstream raw materials:

di-tert-butyl dicarbonate

ethyl 4-aminopiperidine-1-carboxylate

4-Benzylamino-piperidine-1-carboxylic acid ethyl ester

Refernces