Technology Process of 2-(4-(aminomethyl)phenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide
There total 10 articles about 2-(4-(aminomethyl)phenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate; nickel (II) chloride hexahydrate;
In
ethanol;
at 0 - 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; water; ethanol / 2 h / 100 °C / 5250.53 Torr / Inert atmosphere; Microwave irradiation
2: ammonia; hydrogen / methanol / 80 °C / 7500.75 Torr
3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / acetonitrile / 20 °C
4: nickel(II) chloride hexahydrate; sodium tetrahydroborate; ethanol / 2 h / 0 - 20 °C
With
sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium(0); nickel(II) chloride hexahydrate; ethanol; ammonia; hydrogen; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
methanol; ethanol; water; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: ammonia; hydrogen / methanol / 80 °C / 7500.75 Torr
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / acetonitrile / 20 °C
3: nickel(II) chloride hexahydrate; sodium tetrahydroborate; ethanol / 2 h / 0 - 20 °C
With
sodium tetrahydroborate; nickel(II) chloride hexahydrate; ethanol; ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
methanol; acetonitrile;