11-Maleimidoundecanoic Acid Hydrazide

Base Information

• Chemical Name: 11-Maleimidoundecanoic Acid Hydrazide
• CAS No.: 359436-62-7
• Molecular Formula: C15H25N3O3
• Molecular Weight: 295.37700
• DSSTox Substance ID: DTXSID90403304
• Wikidata: Q82206938
• Mol file: 359436-62-7.mol

Synonyms:11-Maleimidoundecanoic Acid Hydrazide;359436-62-7;11-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)undecanehydrazide;11-(2,5-dioxopyrrol-1-yl)undecanehydrazide;11-Maleimidoundecanoic acid hydrazide (KMUH);SCHEMBL2224805;DTXSID90403304;WVGQCJDEFYSDJE-UHFFFAOYSA-N;AMY21538;AKOS027446352;A6248;FT-0604076

Chemical Property of 11-Maleimidoundecanoic Acid Hydrazide

Chemical Property:

• Vapor Pressure: 2.97E-10mmHg at 25°C
• Melting Point: 105-107oC
• Boiling Point: 503.2oC at 760 mmHg
• Flash Point: 258.1oC
• PSA: 92.50000
• Density: 1.128g/cm3
• LogP: 2.44130
• Storage Temp.: -20°C Freezer
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 11
• Exact Mass: 295.18959167
• Heavy Atom Count: 21
• Complexity: 376

Purity/Quality:

98%,99%, ^*data from raw suppliers

11-MaleimidoundecanoicAcidHydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=O)N(C1=O)CCCCCCCCCCC(=O)NN
• Uses: A sulfhydryl and carbonyl reactive heterobifunctional crosslinking reagent. Spacer Arm: 19.0 Angstroms A sulfhydryl and carbonyl reactive heterobifunctional crosslinking reagent.Spacer Arm: 19.0 Angstroms

Technology Process of 11-Maleimidoundecanoic Acid Hydrazide

There total 3 articles about 11-Maleimidoundecanoic Acid Hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.2%

C30H35N3O5 → k-maleimidoundecanoic acid N-hydrazide (359436-62-7)

Guidance literature:

With piperidine; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield:

11-(2,5-dioxopyrrol-1-yl)undecanoic acid (57079-01-3) → k-maleimidoundecanoic acid N-hydrazide (359436-62-7)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride; N,N-dimethyl-formamide / 3 h / Reflux

2: tributyl-amine / dichloromethane / 4 h / 15 - 20 °C

3: piperidine / tetrahydrofuran / 4 h / 20 °C

With piperidine; thionyl chloride; tributyl-amine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

Reference yield:

11-maleimidoundecanoyl chloride (280136-41-6) → k-maleimidoundecanoic acid N-hydrazide (359436-62-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tributyl-amine / dichloromethane / 4 h / 15 - 20 °C

2: piperidine / tetrahydrofuran / 4 h / 20 °C

With piperidine; tributyl-amine; In tetrahydrofuran; dichloromethane;

upstream raw materials:

11-(2,5-dioxopyrrol-1-yl)undecanoic acid

11-maleimidoundecanoyl chloride

Refernces