1-N-PROPYL-1-TOSYLMETHYL ISOCYANIDE

Base Information

• Chemical Name: 1-N-PROPYL-1-TOSYLMETHYL ISOCYANIDE
• CAS No.: 58379-82-1
• Molecular Formula: C12H15NO2S
• Molecular Weight: 237.323
• Mol file: 58379-82-1.mol

Synonyms:1-N-Propyl-1-tosylmethyl isocyanide;1-[(1-Isocyanobutyl)sulfonyl]-4-methylbenzene;1-Isocyanobutyl 4-methylphenyl sulfone;

Chemical Property of 1-N-PROPYL-1-TOSYLMETHYL ISOCYANIDE

Chemical Property:

• PSA: 42.52000
• LogP: 3.12570

Purity/Quality:

98%min ^*data from raw suppliers

1-N-PROPYL-1-TOSYLMETHYL ISOCYANIDE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-N-PROPYL-1-TOSYLMETHYL ISOCYANIDE

There total 2 articles about 1-N-PROPYL-1-TOSYLMETHYL ISOCYANIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

[(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) + propyl bromide (106-94-5) → 1-((1-isocyanobutyl)sulfonyl)-4-methylbenzene (58379-82-1)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; sodium hydroxide; In dichloromethane; water;

DOI:10.1016/j.tet.2020.131674

Reference yield:

→ 1-((1-isocyanobutyl)sulfonyl)-4-methylbenzene (58379-82-1)

Guidance literature:

Tosylmethylisocyanid 1a, Propyljodid;

DOI:10.1016/S0040-4039(00)91390-X

Reference yield: 65.0%

1-Bromonaphthalene (90-11-9) + 1-((1-isocyanobutyl)sulfonyl)-4-methylbenzene (58379-82-1) → α-naphthyl p-methylphenyl sulphone (13249-99-5)

Guidance literature:

With copper(II) acetate monohydrate; In ethylene glycol; at 120 ℃; Sealed tube;

DOI:10.1016/j.tet.2020.131674

upstream raw materials:

[(p-methylphenyl)sulfonylmethyl]isonitrile

propyl bromide

Downstream raw materials:

(4S,5S)-4-Benzyloxymethyl-5-[2-isocyano-2-(toluene-4-sulfonyl)-pentyl]-2,2-dimethyl-[1,3]dioxolane

phenyltolylsulfone

α-naphthyl p-methylphenyl sulphone

Refernces