1H-indazole-3-carbohydrazide

Base Information

• Chemical Name: 1H-indazole-3-carbohydrazide
• CAS No.: 59591-84-3
• Molecular Formula: C8H8N4O
• Molecular Weight: 176.1753
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID70369474
• Nikkaji Number: J1.421.824F
• Wikidata: Q27467854
• Mol file: 59591-84-3.mol

Synonyms:1H-indazole-3-carbohydrazide;59591-84-3;1H-indazole-3-carboxylic acid hydrazide;89977-49-1;2h-indazole-3-carboxylic acid hydrazide;Oprea1_121648;SCHEMBL2021679;DTXSID70369474;JOUPSJAGJHYWLM-UHFFFAOYSA-N;CCG-55508;AKOS000148860;SB37856;A8370;CS-0270280;FT-0604108;EN300-1179970;SR-01000644530-1;Q27467854

Chemical Property of 1H-indazole-3-carbohydrazide

Chemical Property:

• Melting Point: 218-220 °C
• Refractive Index: 1.734
• PKA: 11.92±0.30(Predicted)
• PSA: 83.80000
• Density: 1.436 g/cm³
• LogP: 1.25760
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 176.06981089
• Heavy Atom Count: 13
• Complexity: 208

Purity/Quality:

98%Min ^*data from raw suppliers

1H-Indazole-3-carboxylicacidhydrazide 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=NN2)C(=O)NN

Technology Process of 1H-indazole-3-carbohydrazide

There total 4 articles about 1H-indazole-3-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.63%

ethyl 1H-indazole-3-carboxylate (4498-68-4) → 1H-indazole-3-carboxylic acid hydrazide (59591-84-3)

Guidance literature:

In ethanol; at 78 ℃; for 3h;

DOI:10.1002/jhet.3866

Reference yield: 67.0%

methyl 1H-indazole-3-carboxylate (43120-28-1) → 1H-indazole-3-carboxylic acid hydrazide (59591-84-3)

Guidance literature:

With hydrazine hydrate; In methanol; at 80 ℃; for 6h;

Reference yield:

1H-Indazole-3-carboxylic acid (4498-67-3) → 1H-indazole-3-carboxylic acid hydrazide (59591-84-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 4 h / Reflux

2: hydrazine hydrate / methanol / 6 h / 80 °C

With sulfuric acid; hydrazine hydrate; In methanol;

upstream raw materials:

ethyl 1H-indazole-3-carboxylate

1H-Indazole-3-carboxylic acid

methyl 1H-indazole-3-carboxylate

Downstream raw materials:

1⁽²⁾H-indazole-3-carboxylic acid (4-chloro-benzylidene)-hydrazide

Refernces

• 1、 -. "HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS". . . Retrieved 2018/06/12.
• 2、 -. "TUBULIN INHIBITORS". Paragraph 00220; 00221; 00232. . Retrieved 2013/11/18.