Benzyl 4-bromobutyl ether

Base Information

• Chemical Name: Benzyl 4-bromobutyl ether
• CAS No.: 60789-54-0
• Molecular Formula: C11H15BrO
• Molecular Weight: 243.143
• Hs Code.: 29093090
• Mol file: 60789-54-0.mol

Synonyms:4-bromobutoxymethylbenzene

Chemical Property of Benzyl 4-bromobutyl ether

Chemical Property:

• Vapor Pressure: 0.00439mmHg at 25°C
• Refractive Index: n20/D 1.529(lit.)
• Boiling Point: 287.1 °C at 760 mmHg
• Flash Point: 126.6 °C
• PSA: 9.23000
• Density: 1.27 g/cm³
• LogP: 3.37830
• Storage Temp.: Room temperature.
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Benzyloxy-1-bromobutane(~90%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Benzyl 4-bromobutyl ether may be used for the synthesis of monodisperse oligo(THF), a supramolecular network structure.

Technology Process of Benzyl 4-bromobutyl ether

There total 12 articles about Benzyl 4-bromobutyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-benzyloxy-butan-1-ol (4541-14-4) → 4-bromobutyl benzyl ether (60789-54-0)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In diethyl ether; for 2h; Heating;

DOI:10.1021/ja017136x

Reference yield: 86.0%

1,4-dibromo-butane (110-52-1) + benzyl alcohol (100-51-6,185532-71-2) → 4-bromobutyl benzyl ether (60789-54-0)

Guidance literature:

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; at 70 ℃; for 4h;

DOI:10.1021/ja051775g

Reference yield:

carbon tetrabromide (558-13-4) + 4-benzyloxy-butan-1-ol (4541-14-4) → 4-bromobutyl benzyl ether (60789-54-0)

Guidance literature:

With triphenylphosphine; In dichloromethane;

upstream raw materials:

4-benzyloxy-butan-1-ol

4-Bromo-1-butanol

benzyl bromide

1,4-dibromo-butane

Downstream raw materials:

methyl (2Z)-8-benzyloxy-3-<(diethoxy)phosphoryloxy>-4-methyl-2-octenoate

2-(4-(phenylmethoxy)butyl)-2-cyclohexen-1-one

2-(4-benzyloxybutyl)cyclopentanone

2-(4-benzyloxybutyl)cyclohexanone

Refernces

• 1、 -. "BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE". Paragraph 1000-1001. . Retrieved 2019/10/23.
• 2、 Bernat, Viachaslau,Brox, Regine,Heinrich, Markus R.,Auberson, Yves P.,Tschammer, Nuska. "Ligand-biased and probe-dependent modulation of chemokine receptor CXCR3 signaling by negative allosteric modulators". supporting information. p. 566 - 574. Retrieved 2015/03/13.